• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多糖脂质体作为一种刺激有效免疫反应的新策略及其对树突状细胞的影响。

polysaccharide liposome as a novel strategy for stimulating an efficient immune response and their effects on dendritic cells.

作者信息

Huang Yee, Qin Tao, Huang Yifan, Liu Zhenguang, Bo Ruonan, Hu Yuanliang, Liu Jiaguo, Wu Yi, Wang Deyun

机构信息

College of Veterinary Medicine, Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing.

College of Animal Science and Veterinary Medicine, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China.

出版信息

Int J Nanomedicine. 2016 Dec 14;11:6795-6808. doi: 10.2147/IJN.S119108. eCollection 2016.

DOI:10.2147/IJN.S119108
PMID:28008254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5167497/
Abstract

Nanomedicine, the medical application of nanotechnology, promises a seemingly limitless range of applications from drug delivery to adjuvants and therapeutics. Our current research is focused on natural polymer-based liposome adjuvants. With the aim of inducing protective and long-lasting immunity, the immunological adjuvant activity of polysaccharide liposome (RGPL) was investigated. In vivo, the splenic lymphocyte proliferation ratios and ovalbumin-specific immunoglobulin G titers of ovalbumin-RGPL-vaccinated mice were significantly upregulated. In draining lymph nodes, the expression of MHC IICD11c and CD86CD11c was increased by RGPL; in addition, the percentages of central memory cells (T) and effector memory cells (T) were also elevated. RGPL could effectively provide adequate antigen exposure in lymph nodes. In vitro, RGPL could promote dendritic cell maturation and enhance dendritic cell functions, such as the mixed lymphocyte reaction and antigen presentation. Overall, the results demonstrated that RGPL has the potential to act as an effective controlled release vaccine adjuvant.

摘要

纳米医学，即纳米技术在医学上的应用，有望实现从药物递送、佐剂到治疗等一系列看似无穷无尽的应用。我们目前的研究集中在基于天然聚合物的脂质体佐剂上。为了诱导保护性和持久免疫力，对多糖脂质体（RGPL）的免疫佐剂活性进行了研究。在体内，接种卵清蛋白-RGPL的小鼠的脾淋巴细胞增殖率和卵清蛋白特异性免疫球蛋白G滴度显著上调。在引流淋巴结中，RGPL增加了MHC II CD11c和CD86 CD11c的表达；此外，中央记忆细胞（T）和效应记忆细胞（T）的百分比也有所升高。RGPL可以有效地在淋巴结中提供足够的抗原暴露。在体外，RGPL可以促进树突状细胞成熟并增强树突状细胞功能，如混合淋巴细胞反应和抗原呈递。总体而言，结果表明RGPL有潜力作为一种有效的控释疫苗佐剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/d50a5a24865d/ijn-11-6795Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/ae679ab3de84/ijn-11-6795Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/514523c47e89/ijn-11-6795Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/449313ec2f93/ijn-11-6795Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/a1013028766f/ijn-11-6795Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/d50a5a24865d/ijn-11-6795Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/ae679ab3de84/ijn-11-6795Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/514523c47e89/ijn-11-6795Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/449313ec2f93/ijn-11-6795Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/a1013028766f/ijn-11-6795Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80a8/5167497/d50a5a24865d/ijn-11-6795Fig5.jpg

相似文献

1
polysaccharide liposome as a novel strategy for stimulating an efficient immune response and their effects on dendritic cells.多糖脂质体作为一种刺激有效免疫反应的新策略及其对树突状细胞的影响。
Int J Nanomedicine. 2016 Dec 14;11:6795-6808. doi: 10.2147/IJN.S119108. eCollection 2016.
2
The enhanced immune response of PCV-2 vaccine using Rehmannia glutinosa polysaccharide liposome as an adjuvant.以熟地黄多糖脂质体为佐剂的猪圆环病毒2型疫苗增强的免疫反应。
Int J Biol Macromol. 2016 May;86:929-36. doi: 10.1016/j.ijbiomac.2016.02.003. Epub 2016 Feb 3.
3
Optimization on preparation conditions of Rehmannia glutinosa polysaccharide liposome and its immunological activity.地黄多糖脂质体的制备条件优化及其免疫活性。
Carbohydr Polym. 2014 Apr 15;104:118-26. doi: 10.1016/j.carbpol.2014.01.022. Epub 2014 Jan 17.
4
Rehmannia glutinosa polysaccharide functions as a mucosal adjuvant to induce dendritic cell activation in mediastinal lymph node.地黄多糖作为黏膜佐剂在诱导纵隔淋巴结树突状细胞活化中的作用。
Int J Biol Macromol. 2018 Dec;120(Pt B):1618-1623. doi: 10.1016/j.ijbiomac.2018.09.187. Epub 2018 Sep 30.
5
Immunoenhancement effect of rehmannia glutinosa polysaccharide on lymphocyte proliferation and dendritic cell.地黄多糖对淋巴细胞增殖和树突状细胞的免疫增强作用。
Carbohydr Polym. 2013 Jul 25;96(2):516-21. doi: 10.1016/j.carbpol.2013.04.018. Epub 2013 Apr 18.
6
Salidroside liposome formulation enhances the activity of dendritic cells and immune responses.红景天苷脂质体制剂增强树突状细胞活性和免疫反应。
Int Immunopharmacol. 2013 Dec;17(4):1134-40. doi: 10.1016/j.intimp.2013.10.016. Epub 2013 Nov 1.
7
PEGylated nano-Rehmannia glutinosa polysaccharide induces potent adaptive immunity against Bordetella bronchiseptica.PEGylated 纳米地黄多糖诱导针对支气管败血波氏杆菌的强烈适应性免疫。
Int J Biol Macromol. 2021 Jan 31;168:507-517. doi: 10.1016/j.ijbiomac.2020.12.044. Epub 2020 Dec 10.
8
The immunoregulatory activities of astragalus polysaccharide liposome on macrophages and dendritic cells.黄芪多糖脂质体对巨噬细胞和树突状细胞的免疫调节作用。
Int J Biol Macromol. 2017 Dec;105(Pt 1):852-861. doi: 10.1016/j.ijbiomac.2017.07.108. Epub 2017 Jul 19.
9
Simple nanoliposomes encapsulating polysaccharides as adjuvants improve humoral and cellular immunity in mice.包裹多糖作为佐剂的简单纳米脂质体可增强小鼠的体液免疫和细胞免疫。
Int J Nanomedicine. 2017 Aug 28;12:6289-6301. doi: 10.2147/IJN.S136820. eCollection 2017.
10
Rehmannia glutinosa polysaccharide induces maturation of murine bone marrow derived Dendritic cells (BMDCs).地黄多糖诱导鼠骨髓来源树突状细胞（BMDCs）的成熟。
Int J Biol Macromol. 2013 Mar;54:136-43. doi: 10.1016/j.ijbiomac.2012.12.005. Epub 2012 Dec 12.

引用本文的文献

1
Changes in Rehmanniae Radix processing and their impact on ovarian hypofunction: potential mechanisms of action.地黄炮制变化及其对卵巢功能减退的影响：潜在作用机制
Front Pharmacol. 2024 Jul 3;15:1426972. doi: 10.3389/fphar.2024.1426972. eCollection 2024.
2
Liposomes as Multifunctional Nano-Carriers for Medicinal Natural Products.脂质体作为药用天然产物的多功能纳米载体
Front Chem. 2022 Aug 8;10:963004. doi: 10.3389/fchem.2022.963004. eCollection 2022.
3
A Polysaccharide From the Whole Plant of L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer.

本文引用的文献

1
The enhanced immune response of PCV-2 vaccine using Rehmannia glutinosa polysaccharide liposome as an adjuvant.以熟地黄多糖脂质体为佐剂的猪圆环病毒2型疫苗增强的免疫反应。
Int J Biol Macromol. 2016 May;86:929-36. doi: 10.1016/j.ijbiomac.2016.02.003. Epub 2016 Feb 3.
2
Liposomes as vaccine delivery systems: a review of the recent advances.脂质体作为疫苗递送系统：近期进展综述
Ther Adv Vaccines. 2014 Nov;2(6):159-82. doi: 10.1177/2051013614541440.
3
Topical application of zinc oxide nanoparticles reduces bacterial skin infection in mice and exhibits antibacterial activity by inducing oxidative stress response and cell membrane disintegration in macrophages.
一种来自枸杞全株的多糖增强了基于树突状细胞的乳腺癌免疫疗法的抗肿瘤活性。
Front Pharmacol. 2021 Aug 24;12:678865. doi: 10.3389/fphar.2021.678865. eCollection 2021.
4
Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy.天然多糖及其衍生物：肿瘤免疫治疗中一种有前景的天然佐剂。
Front Pharmacol. 2021 Apr 14;12:621813. doi: 10.3389/fphar.2021.621813. eCollection 2021.
5
DEC-205 receptor-mediated long-circling nanoliposome as an antigen and polysaccharide delivery system enhances the immune response via facilitating dendritic cells maturation.DEC-205受体介导的长效循环纳米脂质体作为一种抗原和多糖递送系统，通过促进树突状细胞成熟增强免疫反应。
Drug Deliv. 2020 Dec;27(1):1581-1596. doi: 10.1080/10717544.2020.1844343.
6
The Effects of Oral Polysaccharide Administration on Immune Responses, Antioxidant Activity and Resistance Against in the Common Carp, L.口服多糖对鲤鱼（L.）免疫反应、抗氧化活性和抗逆性的影响。
Front Immunol. 2020 May 8;11:904. doi: 10.3389/fimmu.2020.00904. eCollection 2020.
7
Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells.中草药及其对肿瘤相关T细胞的调节作用。
Front Pharmacol. 2020 Apr 21;11:492. doi: 10.3389/fphar.2020.00492. eCollection 2020.
8
"Quantity-effect" research strategy for comparison of antioxidant activity and quality of Rehmanniae Radix and Rehmannia Radix Praeparata by on-line HPLC-UV-ABTS assay.在线 HPLC-UV-ABTS 法测定抗氧化活性和质量比较生地黄和熟地黄的“量效”研究策略。
BMC Complement Med Ther. 2020 Jan 17;20(1):16. doi: 10.1186/s12906-019-2798-8.
9
Plant-derived polysaccharides activate dendritic cell-based anti-cancer immunity.植物源多糖激活基于树突状细胞的抗癌免疫。
Cytotechnology. 2018 Aug;70(4):1097-1110. doi: 10.1007/s10616-018-0202-z. Epub 2018 Mar 19.
氧化锌纳米颗粒的局部应用可减少小鼠的细菌性皮肤感染，并通过诱导巨噬细胞的氧化应激反应和细胞膜崩解来展现抗菌活性。
Nanomedicine. 2014 Aug;10(6):1195-208. doi: 10.1016/j.nano.2014.02.012. Epub 2014 Mar 6.
4
Optimization on preparation conditions of Rehmannia glutinosa polysaccharide liposome and its immunological activity.地黄多糖脂质体的制备条件优化及其免疫活性。
Carbohydr Polym. 2014 Apr 15;104:118-26. doi: 10.1016/j.carbpol.2014.01.022. Epub 2014 Jan 17.
5
Nanoparticle vaccines.纳米颗粒疫苗。
Vaccine. 2014 Jan 9;32(3):327-37. doi: 10.1016/j.vaccine.2013.11.069. Epub 2013 Dec 2.
6
Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine.评价单磷酰脂质 A 作为流感疫苗肺部给药的佐剂。
J Control Release. 2014 Jan 28;174:51-62. doi: 10.1016/j.jconrel.2013.11.013. Epub 2013 Nov 21.
7
Aluminium in human sweat.人汗中的铝。
J Trace Elem Med Biol. 2014 Jan;28(1):87-8. doi: 10.1016/j.jtemb.2013.10.002. Epub 2013 Oct 27.
8
The spleen in local and systemic regulation of immunity.脾脏在局部和全身免疫调节中的作用。
Immunity. 2013 Nov 14;39(5):806-18. doi: 10.1016/j.immuni.2013.10.010.
9
Salidroside liposome formulation enhances the activity of dendritic cells and immune responses.红景天苷脂质体制剂增强树突状细胞活性和免疫反应。
Int Immunopharmacol. 2013 Dec;17(4):1134-40. doi: 10.1016/j.intimp.2013.10.016. Epub 2013 Nov 1.
10
Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis.佐剂配方的结构和组成对于开发有效的结核病疫苗至关重要。
J Control Release. 2013 Nov 28;172(1):190-200. doi: 10.1016/j.jconrel.2013.07.030. Epub 2013 Aug 9.