Group of Clinical Genomic Networks, Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, P.R. China.
CNR IAC "Mauro Picone", Via dei Taurini 19 00185-Roma, Italy.
Sci Rep. 2016 Dec 23;6:39043. doi: 10.1038/srep39043.
Degeneration is a hallmark of autoimmune diseases, whose incidence grows worldwide. Current therapies attempt to control the immune response to limit degeneration, commonly promoting immunodepression. Differently, mechanical stimulation is known to trigger healing (regeneration) and it has recently been proposed locally for its therapeutic potential on severely injured areas. As the early stages of healing consist of altered intra- and inter-cellular fluxes of soluble molecules, we explored the potential of this early signal to spread, over time, beyond the stimulation district and become systemic, to impact on distributed or otherwise unreachable injured areas. We report in a model of arthritis in rats how stimulations delivered in the subcutaneous dorsal tissue result, over time, in the control and healing of the degeneration of the paws' joints, concomitantly with the systemic activation of wound healing phenomena in blood and in correlation with a more eubiotic microbiome in the gut intestinal district.
退化是自身免疫性疾病的一个标志，其发病率在全球范围内不断增加。目前的治疗方法试图控制免疫反应以限制退化，通常促进免疫抑制。不同的是，机械刺激已知会引发愈合（再生），最近有人提出在严重受伤区域局部应用机械刺激来发挥其治疗潜力。由于愈合的早期阶段包括细胞内和细胞间可溶性分子的通量改变，我们探讨了这种早期信号传播的潜力，随着时间的推移，信号会超越刺激区域并变得全身系统性，从而影响分布广泛或无法到达的受损区域。我们在大鼠关节炎模型中报告了一种情况，即在皮下背部组织中进行刺激，随着时间的推移，会控制和治愈爪子关节的退化，同时在血液中全身激活伤口愈合现象，并与肠道肠道区更有益的微生物组相关。
