臭牡丹根中的二萜类化合物和苯乙醇苷及其对血管紧张素转换酶和α-葡萄糖苷酶的抑制作用。
Diterpenoids and phenylethanoid glycosides from the roots of Clerodendrum bungei and their inhibitory effects against angiotensin converting enzyme and α-glucosidase.
作者信息
Liu Qing, Hu Hai-Jun, Li Peng-Fei, Yang Ying-Bo, Wu Li-Hong, Chou Gui-Xin, Wang Zheng-Tao
机构信息
The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China.
Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210009, China.
出版信息
Phytochemistry. 2014 Jul;103:196-202. doi: 10.1016/j.phytochem.2014.02.015. Epub 2014 Apr 9.
Abietane derivatives, bungnates A, B, 15-dehydrocyrtophyllone A and 15-dehydro-17-hydroxycyrtophyllone A, and two phenylethanoid glycosides, bunginoside A and 3″,4″-di-O-acetylmartynoside, together with nine known abietane derivatives and fourteen known phenylethanoid glycosides, were isolated from dried roots of Clerodendrum bungei. Their structures were determined on the basis of detailed spectroscopic analyses and acidic hydrolysis. The absolute configuration of bunginoside A was established from analysis of CD data. Selected compounds were evaluated for inhibitory effects against angiotensin converting enzyme (ACE) and α-glucosidase. 15-Dehydrocyrtophyllone A showed an ACE inhibitory effect, and verbascoside, leucosceptoside A and isoacteoside exhibited strong inhibitory capacity against α-glucosidase.
从臭牡丹干燥根中分离得到了枞酸型二萜衍生物、臭牡丹酸A、B、15-脱氢南烛叶酮A和15-脱氢-17-羟基南烛叶酮A，以及两种苯乙醇苷类化合物，臭牡丹苷A和3″,4″-二-O-乙酰马先蒿苷，同时还分离得到了9个已知的枞酸型二萜衍生物和14个已知的苯乙醇苷类化合物。通过详细的光谱分析和酸性水解确定了它们的结构。通过对圆二色数据的分析确定了臭牡丹苷A的绝对构型。对所选化合物进行了抗血管紧张素转换酶（ACE）和α-葡萄糖苷酶抑制活性的评价。15-脱氢南烛叶酮A表现出ACE抑制作用，毛蕊花糖苷、白苞筋骨草苷A和异毛蕊花糖苷对α-葡萄糖苷酶表现出较强的抑制能力。
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