Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Partnership for Dengue Control (PDC), Fondation Mérieux, Lyon, France; Institute of Public Health, University of Heidelberg, Heidelberg, Germany.
Duke-NUS Medical School, Singapore.
Lancet Infect Dis. 2017 Mar;17(3):e101-e106. doi: 10.1016/S1473-3099(16)30518-7. Epub 2016 Dec 21.
For decades, arboviral diseases were considered to be only minor contributors to global mortality and disability. As a result, low priority was given to arbovirus research investment and related public health infrastructure. The past five decades, however, have seen an unprecedented emergence of epidemic arboviral diseases (notably dengue, chikungunya, yellow fever, and Zika virus disease) resulting from the triad of the modern world: urbanisation, globalisation, and international mobility. The public health emergency of Zika virus, and the threat of global spread of yellow fever, combined with the resurgence of dengue and chikungunya, constitute a wake-up call for governments, academia, funders, and WHO to strengthen programmes and enhance research in aedes-transmitted diseases. The common features of these diseases should stimulate similar research themes for diagnostics, vaccines, biological targets and immune responses, environmental determinants, and vector control measures. Combining interventions known to be effective against multiple arboviral diseases will offer the most cost-effective and sustainable strategy for disease reduction. New global alliances are needed to enable the combination of efforts and resources for more effective and timely solutions.
几十年来，虫媒病毒病被认为对全球死亡率和残疾率的影响较小。因此，对虫媒病毒研究投资和相关公共卫生基础设施的重视程度较低。然而，在过去的五十年中，由于现代世界的三重因素：城市化、全球化和国际流动性，出现了前所未有的虫媒病毒病（特别是登革热、基孔肯雅热、黄热病和寨卡病毒病）流行。寨卡病毒的公共卫生紧急情况，以及黄热病在全球传播的威胁，加上登革热和基孔肯雅热的死灰复燃，敲响了警钟，促使各国政府、学术界、资助者和世卫组织加强蚊媒传播疾病的规划并加大研究力度。这些疾病的共同特征应该激发针对诊断、疫苗、生物靶标和免疫反应、环境决定因素以及病媒控制措施的类似研究主题。结合针对多种虫媒病毒病有效的干预措施将提供最具成本效益和可持续的疾病减少策略。需要建立新的全球联盟，以便能够整合努力和资源，以更有效地及时解决问题。
