Khan Uqba, Rizvi Humaira, Ali Farman, Lebovic Daniel
St John Hospital and Medical Center, Detroit, USA.
BMJ Case Rep. 2016 Dec 23;2016:bcr2016217606. doi: 10.1136/bcr-2016-217606.
Sweet syndrome is a rare disorder that is manifested by constellation of clinical features, including fever, neutrophilic leucocytosis, raised painful plaques on skin and dermal infiltration by neutrophils. Numerous aetiological associations have been reported in the literature, including various haematological malignancies and drugs. Our case was peculiar because of association of capecitabine and Sweet syndrome in rectal cancer. We describe a case of a woman aged 57 years, with recently diagnosed stage III rectal cancer, developed painful erythematous rash over her face along with fever and headache. Skin biopsy was performed which revealed typical findings of Sweet syndrome. She was successfully treated with systemic steroids. Our case was an unusual presentation of Sweet syndrome in a patient with rectal adenocarcinoma treated with neoadjuvant capecitabine.
Sweet综合征是一种罕见的疾病，其临床表现为一系列症状，包括发热、中性粒细胞增多、皮肤上出现疼痛性隆起斑块以及中性粒细胞浸润真皮。文献中报道了许多病因关联，包括各种血液系统恶性肿瘤和药物。我们的病例很特殊，因为卡培他滨与直肠癌患者的Sweet综合征有关。我们描述了一例57岁女性患者，最近被诊断为III期直肠癌，面部出现疼痛性红斑皮疹，伴有发热和头痛。进行了皮肤活检，结果显示为Sweet综合征的典型表现。她通过全身使用类固醇成功治愈。我们的病例是在用新辅助卡培他滨治疗的直肠腺癌患者中Sweet综合征的一种不寻常表现。
