Yildiz Ibrahim, Tsvetkova Irina, Wen Amy M, Shukla Sourabh, Masarapu M Hema, Dragnea Bogdan, Steinmetz Nicole F
Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, USA.
RSC Adv. 2012 May 7;2(9):3670-3677. doi: 10.1039/C2RA01376B. Epub 2012 Jan 23.
Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.
病毒纳米颗粒（VNPs）正成为平台技术开发中用途广泛的工具。它们明确的结构以及通过化学和基因修饰的可编程性，使得VNPs能够被设计用于潜在的成像和治疗应用。在本文中，我们报道了多种生物共轭化学在植物VNP（BMV）上的应用。制备了展示荧光染料、聚乙二醇（PEG）分子、化疗药物部分、靶向蛋白和细胞穿透肽多个拷贝的功能性BMV纳米颗粒。这为BMV在纳米医学中的应用打开了大门。
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