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工程病毒纳米颗粒的艺术。

The art of engineering viral nanoparticles.

机构信息

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

出版信息

Mol Pharm. 2011 Feb 7;8(1):29-43. doi: 10.1021/mp100225y. Epub 2010 Dec 17.

Abstract

Viral nanotechnology is an emerging and highly interdisciplinary field in which viral nanoparticles (VNPs) are applied in diverse areas such as electronics, energy and next-generation medical devices. VNPs have been developed as candidates for novel materials, and are often described as "programmable" because they can be modified and functionalized using a number of techniques. In this review, we discuss the concepts and methods that allow VNPs to be engineered, including (i) bioconjugation chemistries, (ii) encapsulation techniques, (iii) mineralization strategies, and (iv) film and hydrogel development. With all these techniques in hand, the potential applications of VNPs are limited only by the imagination.

摘要

病毒纳米技术是一个新兴的高度交叉学科领域,其中病毒纳米粒子(VNPs)被应用于电子、能源和下一代医疗设备等多个领域。VNPs 已被开发为新型材料的候选物,并且通常被描述为“可编程”,因为它们可以使用多种技术进行修饰和功能化。在这篇综述中,我们讨论了允许 VNP 进行工程设计的概念和方法,包括 (i) 生物共轭化学,(ii) 封装技术,(iii) 矿化策略,以及 (iv) 薄膜和水凝胶的开发。有了所有这些技术,VNPs 的潜在应用仅受想象力的限制。

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