Lurie Kristen L, Angst Roland, Seibel Eric J, Liao Joseph C, Ellerbee Bowden Audrey K
Dept. of Electrical Engineering, Stanford University, Stanford, CA, USA; Dept. of Urology, Stanford University, Stanford, CA, USA.
Max Planck Institute, Saarbrücken, Germany.
Biomed Opt Express. 2016 Nov 8;7(12):4995-5009. doi: 10.1364/BOE.7.004995. eCollection 2016 Dec 1.
Despite the trend to pair white light endoscopy with secondary image modalities for in vivo characterization of suspicious lesions, challenges remain to co-register such data. We present an algorithm to co-register two different optical imaging modalities as a mother-daughter endoscopy pair. Using white light cystoscopy (mother) and optical coherence tomography (OCT) (daughter) as an example, we developed the first forward-viewing OCT endoscope that fits in the working channel of flexible cystoscopes and demonstrated our algorithm's performance with optical phantom and clinical imaging data. The ability to register multimodal data opens opportunities for advanced analysis in cancer imaging applications.
尽管目前倾向于将白光内窥镜检查与辅助图像模态相结合以对可疑病变进行体内特征描述,但在共同配准此类数据方面仍存在挑战。我们提出了一种算法,用于将两种不同的光学成像模态作为母子内窥镜对进行共同配准。以白光膀胱镜检查(母)和光学相干断层扫描(OCT)(子)为例,我们开发了首款可适配柔性膀胱镜工作通道的前视OCT内窥镜,并通过光学体模和临床成像数据展示了我们算法的性能。配准多模态数据的能力为癌症成像应用中的高级分析带来了机遇。