Velasco O, Savarino S J, Walton B C, Gam A A, Neva F A
Instituto de Salubridad y Enfermedades Tropicales, Mexico, D.F.
Am J Trop Med Hyg. 1989 Sep;41(3):280-8.
In Mexico, 6 cases of diffuse cutaneous leishmaniasis (DCL) were found in widely separated geographic regions. Information was also available on 2 other cases. In addition to the typical clinical features, half of the patients had evidence of nasopharyngeal mucosal involvement. All isolates from the DCL patients were identified as Leishmania mexicana mexicana by isoenzyme analysis and monoclonal antibody typing. In 1 region of Tabasco state where DCL was found, uncomplicated cutaneous leishmaniasis appeared to be highly endemic, and isolates from a few such patients were identified as L. mexicana mexicana. An incidental finding was the recovery of an isolate of L. braziliensis braziliensis from a patient with chiclero ulcer in Oaxaca state. The clinical and epidemiological significance of the reported cases are discussed.
在墨西哥，在地域相隔甚远的不同地区发现了6例弥漫性皮肤利什曼病（DCL）。另外还有2例病例的相关信息。除了典型的临床特征外，一半的患者有鼻咽部黏膜受累的证据。通过同工酶分析和单克隆抗体分型，所有DCL患者的分离株均被鉴定为墨西哥利什曼原虫墨西哥亚种。在发现DCL的塔巴斯科州的一个地区，非复杂性皮肤利什曼病似乎高度流行，少数此类患者的分离株被鉴定为墨西哥利什曼原虫墨西哥亚种。一个偶然的发现是在瓦哈卡州从一名患有奇克罗溃疡的患者身上分离出一株巴西利什曼原虫巴西亚种。文中讨论了所报告病例的临床和流行病学意义。
