Faculty of Health Sciences, Trinity College, University of Dublin, Dublin, Ireland.
Ir J Med Sci. 2012 Jun;181(2):225-9. doi: 10.1007/s11845-011-0788-z. Epub 2011 Dec 28.
The clinical spectrum of adult coeliac disease (ACD) is varied with limited Irish data.
The aim of this study was to analyse the presenting symptoms, associated conditions and complications in a consecutive series of patients with ACD.
Data were obtained from database on patients with ACD between 1988 and 2004.
One hundred and six patients (69F:37M, mean age: 46, range: 23-95 years) were included. The modes of presentation were diarrhoea in 44 patients (45%), weight loss in 41 (42%), anaemia in 37 (38%), abdominal pain in 15 (15%), fatigue in 8 (8%), hypocalcaemia in 4 (4%) and steatorrhoea in 4 (4%). Associated conditions included thyroid disorders in 7 patients (7%), bipolar affective disorder in 4 (4%), major depression in 3 (3%), rheumatoid disease in 3 (3%), inflammatory bowel disease in 4 (4%) and type I diabetes mellitus in 2 (2%). Malignancy emerged as a major complication in 15 patients (15%)
The presenting features of ACD are diverse and associated with high risk of malignancy.
成人乳糜泻（ACD）的临床表现多样，爱尔兰的相关数据有限。
本研究旨在分析一系列连续的 ACD 患者的首发症状、相关疾病和并发症。
我们从 1988 年至 2004 年间数据库中获取了 ACD 患者的数据。
共纳入 106 例患者（69 例女性：37 例男性，平均年龄 46 岁，范围 23-95 岁）。主要表现为腹泻 44 例（45%）、体重减轻 41 例（42%）、贫血 37 例（38%）、腹痛 15 例（15%）、疲劳 8 例（8%）、低钙血症 4 例（4%）和脂肪泻 4 例（4%）。相关疾病包括甲状腺疾病 7 例（7%）、双相情感障碍 4 例（4%）、重度抑郁症 3 例（3%）、类风湿性疾病 3 例（3%）、炎症性肠病 4 例（4%）和 1 型糖尿病 2 例（2%）。15 例（15%）患者出现恶性肿瘤并发症。
ACD 的首发症状多种多样，且与恶性肿瘤风险增加相关。
