2型糖尿病患者血浆脑源性神经营养因子水平与过早认知障碍/痴呆
Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes.
作者信息
Murillo Ortíz Blanca, Ramírez Emiliano Joel, Ramos-Rodríguez Edna, Martínez-Garza Sandra, Macías-Cervantes Hilda, Solorio-Meza Sergio, Pereyra-Nobara Texar Alfonso
机构信息
Blanca Murillo Ortíz, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara, Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad No. 1 Bajio, Instituto Mexicano del Seguro Social, Guanajuato 37320, Mexico.
出版信息
World J Diabetes. 2016 Dec 15;7(20):615-620. doi: 10.4239/wjd.v7.i20.615.
AIM
To assess the relationship of brain-derived neurotrophic factor (BDNF) with cognitive impairment in patients with type 2 diabetes.
METHODS
The study included 40 patients with diabetes mellitus type 2 (DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy (HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive impairment.
RESULTS
The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment. The levels of BDNF showed significant differences between patients with DM2 (43.78 ± 9.05 31.55 ± 10.24, = 0.005). There were no differences between patients in HD (11.39 ± 8.87 11.11 ± 10.64 = 0.77); interestingly, ferritin levels were higher in patients with cognitive impairment (1564 ± 1335 664 ± 484 = 0.001). The comparison of BDNF values, using a Kruskal Wallis test, between patients with DM2, in HD and healthy controls showed statistical differences ( < 0.001).
CONCLUSION
Low levels of BDNF are associated with cognitive impairment in patients with DM2. The decrease of BDNF occurs early and progressively in patients in HD.
目的
评估脑源性神经营养因子（BDNF）与2型糖尿病患者认知障碍之间的关系。
方法
该研究纳入了40例2型糖尿病（DM2）患者、37例接受血液透析（HD）治疗的慢性肾病患者以及40名健康受试者。采用酶联免疫吸附测定法（ELISA）对血清中的BDNF进行定量。使用简易精神状态检查表（Folstein Mini-Mental State Examination）评估认知障碍。
结果
DM2患者和HD患者被分为两组，即有认知障碍组和无认知障碍组。BDNF水平在DM2患者之间存在显著差异（43.78±9.05对31.55±10.24，P = 0.005）。HD患者之间无差异（11.39±8.87对11.11±10.64，P = 0.77）；有趣的是，认知障碍患者的铁蛋白水平更高（1564±1335对664±484，P = 0.001）。使用Kruskal Wallis检验比较DM2患者、HD患者和健康对照组之间的BDNF值，显示存在统计学差异（P < 0.001）。
结论
BDNF水平低与DM2患者的认知障碍相关。HD患者中BDNF水平的降低早期即出现且呈进行性。
Zotero 插件