Abdulsattar Safaa H, Hasan Riyadh M, Hindoush Laith N
Department of Surgery, Al-Kindy Teaching Hospital.
Al-Kindy College of Medicine, Baghdad, Iraq.
Ann Med Surg (Lond). 2023 Apr 5;85(5):1442-1447. doi: 10.1097/MS9.0000000000000192. eCollection 2023 May.
Several studies had been conducted on the association between blood group ABO and the risk of gastrointestinal malignancies, such as gastric and pancreatic cancer. Studies have also been conducted on the risk of obesity with colorectal carcinoma (CRC). It is unclear whether there is an association between blood group ABO and CRC and which group is more affected.
The aim of this study was to show an association between the ABO blood group, Rh factor, and obesity with CRC.
One hundred and two patients with CRC were included in our case-control study. Blood group, Rh factor, and BMI were estimated and compared with a control group of 180 Iraqis who came to the Endoscopy Department of Al-Kindy Teaching Hospital for preoperative control colonoscopy between January 2016 and January 2019.
The overall distributions of ABO and Rh factor were comparable between patients (41.17% A+, 5.88% A-, 6.86% B+, 2.94 B-, 1.96% AB+, 1.96% AB-, 37.25% O+, and 1.96% O-) and controls (26.66% A+, 1.11% A-, 20% B+, 1.11 B-, 13.3% AB+, 1.11% AB-, 34.44% O+, and 2.22% O-). Statistically, there were significant differences between patients with CRC and control subjects in terms of their blood groups. The A+ group was found in 42 cases (41.17%), followed by O+ in 38 cases (37.25%). Their BMI ranged from 18.5 to 40 kg/m. Overweight patients were more common in 46 cases (45%) followed by obesity class І 32 cases (32.37%) with a -value of 0.00016. Sixty-two of the patients with CRC (60.78%) were male and 40 cases (39.21%) were female. Their ages ranged from 30 to 79 years with a mean age of 55.49 years. CRC 37 cases occurred in the age group of 60-69 years (36.27).
In this study, a statistically significant association was found between the occurrence of CRC and patients with blood group A+, O+, overweight, and obesity class І.
已经进行了多项关于ABO血型与胃肠道恶性肿瘤（如胃癌和胰腺癌）风险之间关联的研究。也有关于肥胖与结直肠癌（CRC）风险的研究。目前尚不清楚ABO血型与CRC之间是否存在关联以及哪一组受影响更大。
本研究的目的是揭示ABO血型、Rh因子以及肥胖与CRC之间的关联。
我们的病例对照研究纳入了102例CRC患者。对血型、Rh因子和体重指数进行评估，并与2016年1月至2019年1月期间到金迪教学医院内镜科进行术前结肠镜检查的180名伊拉克对照组患者进行比较。
患者（41.17% A+、5.88% A-、6.86% B+、2.94% B-、1.96% AB+、1.96% AB-、37.25% O+和1.96% O-）和对照组（26.66% A+、1.11% A-、20% B+、1.11% B-、13.3% AB+、1.11% AB-、34.44% O+和2.22% O-）之间ABO和Rh因子的总体分布具有可比性。在统计学上，CRC患者与对照受试者在血型方面存在显著差异。发现A+组有42例（41.17%），其次是O+组有38例（37.25%）。他们的体重指数范围为18.5至40kg/m²。超重患者更为常见，有46例（45%），其次是I类肥胖患者32例（32.37%），P值为0.00016。62例CRC患者（60.78%）为男性，40例（39.21%）为女性。他们的年龄范围为30至79岁，平均年龄为55.49岁。37例CRC发生在60 - 69岁年龄组（36.27%）。
在本研究中，发现CRC的发生与A+、O+血型患者、超重和I类肥胖之间存在统计学上的显著关联。
