Li Jer-Chuan, Wu Du-An, Hou Jia-Sian, Subeq Yi-Maun, Chen Hsin-Dean, Hsu Bang-Gee
Division of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Division of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.
J Diabetes Res. 2016;2016:8380279. doi: 10.1155/2016/8380279. Epub 2016 Nov 29.
Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM volunteers. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Among 165 DM patients, 113 patients (68.5%) had MetS. Diabetic persons who had MetS had significantly higher A-FABP levels ( < 0.001) than those without MetS. Female DM persons had higher A-FABP level than man ( < 0.001). No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass ( < 0.001), logarithmically transformed creatinine (log-creatinine; < 0.001), female DM patients ( < 0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; = 0.013) were positively correlated, while albumin ( = 0.004) and glomerular filtration rate (GFR; = 0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. In this study, higher serum A-FABP level was positively associated with MetS in type 2 DM patients.
脂肪细胞脂肪酸结合蛋白（A-FABP）是肥胖相关代谢综合征（MetS）的关键介质。本研究旨在评估2型糖尿病（DM）患者中A-FABP浓度与MetS之间的关系。从165名2型DM志愿者中采集空腹血样。使用国际糖尿病联盟的诊断标准定义MetS及其组成成分。在165名DM患者中，113名患者（68.5%）患有MetS。患有MetS的糖尿病患者的A-FABP水平显著高于未患MetS的患者（<0.001）。女性DM患者的A-FABP水平高于男性（<0.001）。在使用他汀类药物、贝特类药物或抗糖尿病药物的患者中，未发现A-FABP水平有统计学显著差异。多变量向前逐步线性回归分析显示，2型DM患者的体脂量（<0.001）、对数转换后的肌酐（log-肌酐；<0.001）、女性DM患者（<0.001）和对数转换后的高敏C反应蛋白（log-hs-CRP；=0.013）与血清A-FABP水平呈正相关，而白蛋白（=0.004）和肾小球滤过率（GFR；=0.043）与血清A-FABP水平呈负相关。在本研究中，2型DM患者中较高的血清A-FABP水平与MetS呈正相关。
