Øverby Anders, Murayama Somay Y, Michimae Hirofumi, Suzuki Hidekazu, Suzuki Masayuki, Serizawa Hiroshi, Tamura Ryo, Nakamura Shinichi, Takahashi Shinichi, Nakamura Masahiko
Center for Clinical Pharmacy and Clinical Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan.
Digestion. 2017;95(1):61-66. doi: 10.1159/000452400. Epub 2017 Jan 5.
Non-Helicobacter pylori-helicobacters (NHPH) compose a group of gram negative zoonotic bacteria that may induce in humans gastric diseases including gastritis, gastroduodenal ulcer and MALT lymphoma. Their prevalence in the general population has previously been reported to 0.1-6.2%, although such reports still remain less in number.
This study aimed at estimating the prevalence of gastric NHPH in Japanese people, and further aimed at linking this to different gastric diseases and co-infection with H. pylori.
Endoscopically obtained biopsy samples from 280 Japanese patients with various gastric diseases were collected. Samples were analyzed by immunohistochemistry and by species-specific PCR for detection of gastric helicobacters.
The total prevalence of gastric NHPH among 280 Japanese patients was 6.1%, and the prevalence of H. pylori was 65.7%. There was no significant difference in prevalence of either NHPH or H. pylori when infected with H. pylori or NHPH, respectively. NHPH infection was found to be the highest in patients with gastric MALT lymphoma and duodenal ulcer, the former being independent of co-infection with H. pylori and the latter being dependent.
This study reports a total prevalence of 6.1% of gastric NHPH in Japanese patients, and further highlights gastric MALT lymphoma and duodenal ulcer (when co-infected with H. pylori) as important related diseases.
非幽门螺杆菌属螺杆菌（NHPH）是一组革兰氏阴性人畜共患病细菌，可在人类中引发包括胃炎、胃十二指肠溃疡和黏膜相关淋巴组织淋巴瘤在内的胃部疾病。此前报道其在普通人群中的患病率为0.1%-6.2%，不过此类报道数量仍然较少。
本研究旨在评估日本人群中胃部NHPH的患病率，并进一步将其与不同胃部疾病以及与幽门螺杆菌的合并感染联系起来。
收集了280例患有各种胃部疾病的日本患者经内镜获取的活检样本。通过免疫组织化学和物种特异性PCR对样本进行分析，以检测胃部螺杆菌。
280例日本患者中胃部NHPH的总患病率为6.1%，幽门螺杆菌的患病率为65.7%。分别感染幽门螺杆菌或NHPH时，NHPH或幽门螺杆菌的患病率均无显著差异。发现胃部黏膜相关淋巴组织淋巴瘤和十二指肠溃疡患者中NHPH感染率最高，前者与幽门螺杆菌合并感染无关，后者与之有关。
本研究报告了日本患者中胃部NHPH的总患病率为6.1%，并进一步强调胃部黏膜相关淋巴组织淋巴瘤和十二指肠溃疡（与幽门螺杆菌合并感染时）是重要的相关疾病。
