Romańczuk Bartosz, Szaflarska-Popławska Anna, Chełchowska Magdalena, Hozyasz Kamil K
Department and Clinic of Paediatrics, Allergology, and Gastroenterology, Nicolaus Copernicus University in Torun, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland.
Department of Paediatric Endoscopy and Gastrointestinal Function Testing, Nicolaus Copernicus University in Torun, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland.
Prz Gastroenterol. 2016;11(4):282-285. doi: 10.5114/pg.2016.61354. Epub 2016 Jul 20.
Consumption of gluten proteins leads to an enteropathy characterised by lymphocytic infiltration of mucous membrane, crypts hypertrophy, and atrophy of villi. Enteropathy leads to disturbances in the immune system as well as secondary deficiency of vitamin E.
Analysis of the concentration of vitamin E in erythrocytes of patients with celiac disease.
Three experimental groups were distinguished among 77 patients with histologically confirmed celiac disease (mean age: 17 years): those who strictly respected gluten-free diet (group I, = 48), patients breaking dietary recommendations (group II, = 22), and those with newly diagnosed disease (group III, = 7). Additionally, a control group consisting of healthy individuals with negative serological markers of celiac disease was formed (group IV, = 20). Vitamin E concentration was determined by high performance liquid chromatography with ultraviolet detector.
Significantly lower average concentration of vitamin E was demonstrated in erythrocytes in all examined groups of patients with celiac disease compared to the control group. Among the patients with celiac disease, the highest average concentration of vitamin E in erythrocytes was observed in the group who respected the gluten-free diet, a little lower in patients who violated dietary recommendations, and lowest among patients with newly diagnosed disease. These relationships, however, were not statistically significant.
Patients with celiac disease are at risk of vitamin E deficiency irrespective of their diet. Vitamin supplementation should be considered in their case, especially immediately after diagnosis of the disease and in case of breaking a gluten-free diet regime.
摄入麸质蛋白会导致一种肠病，其特征为黏膜淋巴细胞浸润、隐窝肥大以及绒毛萎缩。肠病会导致免疫系统紊乱以及维生素E继发性缺乏。
分析乳糜泻患者红细胞中维生素E的浓度。
在77例经组织学确诊为乳糜泻的患者（平均年龄：17岁）中区分出三个实验组：严格遵守无麸质饮食的患者（第一组，n = 48）、违反饮食建议的患者（第二组，n = 22）以及新诊断出疾病的患者（第三组，n = 7）。此外，组建了一个由乳糜泻血清学标志物呈阴性的健康个体组成的对照组（第四组，n = 20）。通过带紫外检测器的高效液相色谱法测定维生素E浓度。
与对照组相比，所有检查的乳糜泻患者组红细胞中维生素E的平均浓度均显著降低。在乳糜泻患者中，红细胞中维生素E平均浓度最高的是遵守无麸质饮食的组，违反饮食建议的患者略低，新诊断出疾病的患者中最低。然而，这些关系无统计学意义。
无论饮食如何，乳糜泻患者都有维生素E缺乏的风险。对于他们，应考虑补充维生素，尤其是在疾病刚诊断后以及违反无麸质饮食方案的情况下。
