Department of Chemistry and Biodynamics of Food, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10 Str., 10-748 Olsztyn, Poland.
Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Białystok, Waszyngtona 17 Str., 15-274 Białystok, Poland.
Nutrients. 2018 Nov 15;10(11):1768. doi: 10.3390/nu10111768.
Prebiotics have been shown to improve absorption of some nutrients, including vitamins. This pilot study evaluated the effect of the prebiotic oligofructose-enriched inulin (Synergy 1) on fat-soluble vitamins status, parathormone, and calcium-related elements in pediatric celiac disease (CD) patients ( = 34) on a strict gluten-free diet (GFD). Participants were randomized into a group receiving 10 g of Synergy 1 or placebo (maltodextrin) together with a GFD. At baseline and after 3 months of intervention, 25-hydroxyvitamin D [25(OH)D], parathormone, vitamin E and A, calcium, phosphate, magnesium, total protein, and albumin were determined. Concentration of 25(OH)D increased significantly ( < 0.05) by 42% in CD patients receiving Synergy 1 in GFD, whereas no change was observed in placebo. Vitamin D status reached an optimal level in 46% of patients receiving Synergy 1. No significant difference in parathormone, calcium, and phosphate levels was observed. Concentration of vitamin E increased significantly ( < 0.05) by 19% in patients receiving Synergy 1, but not in the placebo. Vitamin A levels were not changed. Supplementation of GFD with Synergy 1 improved vitamin D and vitamin E status in children and adolescents with CD and could be considered a novel complementary method of management of fat-soluble vitamins deficiency in pediatric CD patients.
益生元已被证明可以改善某些营养素的吸收，包括维生素。这项初步研究评估了富含低聚果糖的菊粉（Synergy 1）对严格无麸质饮食（GFD）的小儿乳糜泻（CD）患者（n = 34）的脂溶性维生素状态、甲状旁腺激素和钙相关元素的影响。参与者被随机分为两组，一组接受 10 克 Synergy 1，另一组接受安慰剂（麦芽糊精）和 GFD。在基线和干预 3 个月后，测定 25-羟维生素 D [25（OH）D]、甲状旁腺激素、维生素 E 和 A、钙、磷、镁、总蛋白和白蛋白。接受 GFD 中 Synergy 1 的 CD 患者的 25（OH）D 浓度显著增加（<0.05），增加了 42%，而安慰剂组则没有变化。接受 Synergy 1 的患者中有 46%达到了最佳维生素 D 状态。甲状旁腺激素、钙和磷水平没有显著差异。接受 Synergy 1 的患者的维生素 E 浓度显著增加（<0.05），增加了 19%，而安慰剂组则没有变化。维生素 A 水平没有变化。在 GFD 中添加 Synergy 1 可改善 CD 儿童和青少年的维生素 D 和维生素 E 状态，可被视为小儿 CD 患者脂溶性维生素缺乏症的一种新的补充治疗方法。
