Nishihira Jun, Nishimura Mie, Tanaka Aiko, Yamaguchi Akihiro, Taira Toshio
Department of Medical Management and Informatics, Hokkaido Information University, Hokkaido, Japan.
Primary Cell Division, Cosmo Bio Co., Ltd., Sapporo, Japan.
J Tradit Complement Med. 2015 Dec 11;7(1):110-116. doi: 10.1016/j.jtcme.2015.11.002. eCollection 2017 Jan.
This was placebo-controlled double-blind parallel-group comparative clinical trial targeting 80 men and women aged 50-79 years with halitosis and body and fecal odor. We investigated whether daily champignon extract ingestion for 4 weeks improved these conditions. Subjects were divided into four groups: a placebo group and 50, 500, and 1000 mg/day ingestion groups. No severe adverse events or side effects were noted during the study period. Compared with the placebo group, all champignon extract ingestion groups showed improvement or tendency toward improvement in halitosis and body and fecal odor. Furthermore, our results suggested that the effectiveness of champignon extract in alleviating odors is dose-dependent, i.e., it increases with the dosage.
这是一项安慰剂对照、双盲、平行组比较临床试验，目标对象为80名年龄在50至79岁之间、有口臭以及身体和粪便异味的男性和女性。我们研究了连续4周每日摄入香菇提取物是否能改善这些状况。受试者被分为四组：一个安慰剂组以及每日摄入50毫克、500毫克和1000毫克的组。在研究期间未观察到严重不良事件或副作用。与安慰剂组相比，所有香菇提取物摄入组在口臭以及身体和粪便异味方面均有改善或改善趋势。此外，我们的结果表明香菇提取物减轻异味的效果具有剂量依赖性，即随剂量增加而增强。
