N-键合烯醇的取代吗啉的非对映选择性合成：(±)-Chelonin A 的全合成。
Diastereoselective Synthesis of Substituted Morpholines from N-Tethered Alkenols: Total Synthesis of (±)-Chelonin A.
机构信息
Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
出版信息
J Org Chem. 2017 Feb 3;82(3):1330-1339. doi: 10.1021/acs.joc.6b02260. Epub 2017 Jan 18.
PMID:28055209
Abstract
Intramolecular cyclization of nitrogen tethered alkenols catalyzed by palladium chloride leads to substituted morpholines in good yields. The methodology was used for the total synthesis of (±)-chelonin A.
摘要
氮原子连接的烯醇在氯化钯的催化下发生分子内环化反应，得到取代的吗啉，产率良好。该方法用于（±）-龟毒素 A 的全合成。
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