Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Institute of Clinical Pharmacy, Central South University, Changsha, 410011, Hunan, China.
Drug Deliv Transl Res. 2022 Oct;12(10):2287-2302. doi: 10.1007/s13346-021-01110-5. Epub 2022 Jan 4.
Nanoparticle drug delivery systems (NDDSs) are promising platforms for efficient delivery of drugs. In the past decades, many nanomedicines have received clinical approval and completed translation. With the rapid advance of nanobiotechnology, natural vectors are emerging as novel strategies to carry and delivery nanoparticles and drugs for biomedical applications. Among diverse types of cells, macrophage is of great interest for their essential roles in inflammatory and immune responses. Macrophage-derived vesicles (MVs), including exosomes, microvesicles, and those from reconstructed membranes, may inherit the chemotactic migration ability and high biocompatibility. The unique properties of MVs make them competing candidates as novel drug delivery systems for precision nanomedicine. In this review, the advantages and disadvantages of existing NDDSs and MV-based drug delivery systems (MVDDSs) were compared. Then, we summarized the potential applications of MVDDSs and discuss future perspectives. The development of MVDDS may provide avenues for the treatment of diseases involving an inflammatory process.
纳米药物传递系统（NDDS）是高效传递药物的有前途的平台。在过去的几十年中，许多纳米药物已经获得了临床批准并完成了转化。随着纳米生物技术的快速发展，天然载体作为携带和传递纳米颗粒和药物用于生物医学应用的新策略正在出现。在不同类型的细胞中，巨噬细胞因其在炎症和免疫反应中的重要作用而备受关注。巨噬细胞衍生的囊泡（MVs），包括外泌体、微泡和重建膜来源的囊泡，可能继承趋化迁移能力和高生物相容性。MVs 的独特性质使它们成为新型药物传递系统的有竞争力的候选者，用于精准纳米医学。在这篇综述中，比较了现有的 NDDS 和基于 MV 的药物传递系统（MVDDS）的优缺点。然后，我们总结了 MVDDS 的潜在应用，并讨论了未来的前景。MVDDS 的发展可能为涉及炎症过程的疾病的治疗提供途径。
