Cipolla Cynthia M, Lodhi Irfan J
Division of Endocrinology, Metabolism & Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Division of Endocrinology, Metabolism & Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Trends Endocrinol Metab. 2017 Apr;28(4):297-308. doi: 10.1016/j.tem.2016.12.003. Epub 2017 Jan 4.
Peroxisomes carry out many key functions related to lipid and reactive oxygen species (ROS) metabolism. The fundamental importance of peroxisomes for health in humans is underscored by the existence of devastating genetic disorders caused by impaired peroxisomal function or lack of peroxisomes. Emerging studies suggest that peroxisomal function may also be altered with aging and contribute to the pathogenesis of a variety of diseases, including diabetes and its related complications, neurodegenerative disorders, and cancer. With increasing evidence connecting peroxisomal dysfunction to the pathogenesis of these acquired diseases, the possibility of targeting peroxisomal function in disease prevention or treatment becomes intriguing. Here, we review recent developments in understanding the pathophysiological implications of peroxisomal dysfunctions outside the context of inherited peroxisomal disorders.
过氧化物酶体执行许多与脂质和活性氧（ROS）代谢相关的关键功能。过氧化物酶体功能受损或缺乏过氧化物酶体导致的毁灭性遗传疾病的存在，凸显了过氧化物酶体对人类健康的根本重要性。新出现的研究表明，过氧化物酶体功能也可能随着衰老而改变，并促成包括糖尿病及其相关并发症、神经退行性疾病和癌症在内的多种疾病的发病机制。随着越来越多的证据将过氧化物酶体功能障碍与这些后天性疾病的发病机制联系起来，在疾病预防或治疗中针对过氧化物酶体功能的可能性变得引人关注。在这里，我们综述了在遗传性过氧化物酶体疾病背景之外理解过氧化物酶体功能障碍病理生理学意义的最新进展。
