Ramkumar Rajendiran, Balasubramani Govindasamy, Raja Ramalingam Karthik, Raja Manickam, Govindan Raji, Girija Easwaradas Kreedapathy, Perumal Pachiappan
a Department of Biotechnology , Padmavani Arts and Science College for Women , Salem , India.
b Department of Biotechnology , School of Biosciences, Periyar University , Salem , India.
Artif Cells Nanomed Biotechnol. 2017 Jun;45(4):748-757. doi: 10.1080/21691401.2016.1276923. Epub 2017 Jan 9.
The Lantana camara Linn root extract derived gold nanoparticles (Au NPs) were characterized by Ultraviolet-Visible spectroscopy, X-ray diffraction, fourier transform-infrared, high resolution transmission electron microscopy, selected area electron diffraction pattern and energy dispersive X-ray analyses. In DPPH assay, the inhibitory concentration (IC) of Au NPs and gallic acid was 24.17 and 5.39 μg/ml, whereas, for cytotoxicity assay, the IC of Au NPs was 17.72 and 32.98 μg/ml on MBA-MB-231 and Vero cells, respectively. Thus, the Au NPs possess significant in vitro antioxidant and cytotoxic properties which could be considered as potential alternate for the development of anticancer drug in future.
对马缨丹根提取物衍生的金纳米颗粒（Au NPs）进行了紫外可见光谱、X射线衍射、傅里叶变换红外光谱、高分辨率透射电子显微镜、选区电子衍射图谱和能量色散X射线分析表征。在DPPH测定中，Au NPs和没食子酸的抑制浓度（IC）分别为24.17和5.39μg/ml，而在细胞毒性测定中，Au NPs对MBA-MB-231和Vero细胞的IC分别为17.72和32.98μg/ml。因此，Au NPs具有显著的体外抗氧化和细胞毒性特性，未来可被视为开发抗癌药物的潜在替代品。
