Kim Anmo J, Fenk Lisa M, Lyu Cheng, Maimon Gaby
Laboratory of Integrative Brain Function, The Rockefeller University, New York, NY 10065, USA.
Laboratory of Integrative Brain Function, The Rockefeller University, New York, NY 10065, USA.
Cell. 2017 Jan 12;168(1-2):280-294.e12. doi: 10.1016/j.cell.2016.12.005. Epub 2017 Jan 5.
Vision influences behavior, but ongoing behavior also modulates vision in animals ranging from insects to primates. The function and biophysical mechanisms of most such modulations remain unresolved. Here, we combine behavioral genetics, electrophysiology, and high-speed videography to advance a function for behavioral modulations of visual processing in Drosophila. We argue that a set of motion-sensitive visual neurons regulate gaze-stabilizing head movements. We describe how, during flight turns, Drosophila perform a set of head movements that require silencing their gaze-stability reflexes along the primary rotation axis of the turn. Consistent with this behavioral requirement, we find pervasive motor-related inputs to the visual neurons, which quantitatively silence their predicted visual responses to rotations around the relevant axis while preserving sensitivity around other axes. This work proposes a function for a behavioral modulation of visual processing and illustrates how the brain can remove one sensory signal from a circuit carrying multiple related signals.
视觉会影响行为，但从昆虫到灵长类动物，持续的行为也会调节视觉。大多数此类调节的功能和生物物理机制仍未得到解决。在这里，我们结合行为遗传学、电生理学和高速摄像技术，来推进对果蝇视觉处理行为调节的一种功能的研究。我们认为，一组对运动敏感的视觉神经元调节稳定注视的头部运动。我们描述了在飞行转弯过程中，果蝇如何进行一系列头部运动，这些运动需要沿着转弯的主旋转轴抑制它们的注视稳定反射。与这种行为需求一致，我们发现视觉神经元存在广泛的与运动相关的输入，这些输入会定量地抑制它们对围绕相关轴旋转的预测视觉反应，同时保留对其他轴的敏感性。这项工作提出了视觉处理行为调节的一种功能，并说明了大脑如何从携带多个相关信号的回路中去除一个感觉信号。
