Laboratory of Integrative Brain Function and Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA; Active Sensing, Max Plank Institute of Neurobiology, Martinsried, Germany.
Laboratory of Integrative Brain Function and Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA; Department of Biomedical Engineering, Hanyang University, Seoul, South Korea; Department of Electronic Engineering, Hanyang University, Seoul, South Korea.
Curr Biol. 2021 Oct 25;31(20):4608-4619.e3. doi: 10.1016/j.cub.2021.09.068. Epub 2021 Oct 12.
From mammals to insects, locomotion has been shown to strongly modulate visual-system physiology. Does the manner in which a locomotor act is initiated change the modulation observed? We performed patch-clamp recordings from motion-sensitive visual neurons in tethered, flying Drosophila. We observed motor-related signals in flies performing flight turns in rapid response to looming discs and also during spontaneous turns, but motor-related signals were weak or non-existent in the context of turns made in response to brief pulses of unidirectional visual motion (i.e., optomotor responses). Thus, the act of a locomotor turn is variably associated with modulation of visual processing. These results can be understood via the following principle: suppress visual responses during course-changing, but not course-stabilizing, navigational turns. This principle is likely to apply broadly-even to mammals-whenever visual cells whose activity helps to stabilize a locomotor trajectory or the visual gaze angle are targeted for motor modulation.
从哺乳动物到昆虫，运动已被证明会强烈调节视觉系统的生理学。运动行为的启动方式是否会改变观察到的调制？我们对拴系、飞行的果蝇中的运动敏感视觉神经元进行了膜片钳记录。我们观察到飞行中的苍蝇在快速响应逼近的圆盘时会产生与运动相关的信号，也会在自发转弯时产生，但在响应单向视觉运动（即光运动反应）的短暂脉冲时，与运动相关的信号很弱或不存在。因此，运动转弯的行为与视觉处理的调制有关。这些结果可以通过以下原理来理解：在改变航向而不是稳定航向的导航转弯过程中抑制视觉反应。只要针对那些有助于稳定运动轨迹或视觉注视角度的视觉细胞进行运动调制，这个原理就很可能广泛适用——即使是在哺乳动物中。
