Jiang Chunxiang, Yi Li, Su Shi, Shi Caiyun, Long Xiaojing, Xie Guoxi, Zhang Lijuan
Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, China.
Department of Neurology, Peking University Shenzhen Hospital Shenzhen, China.
Front Hum Neurosci. 2016 Dec 20;10:634. doi: 10.3389/fnhum.2016.00634. eCollection 2016.
It remains an ongoing investigation about how the neural activity alters with the diurnal rhythms in human brain. Resting-state functional magnetic resonance imaging (RS-fMRI) reflects spontaneous activities and/or the endogenous neurophysiological process of the human brain. In the present study, we applied the ReHo (regional homogeneity) and ALFF (amplitude of low frequency fluctuation) based on RS-fMRI to explore the regional differences in the spontaneous cerebral activities throughout the entire brain between the morning and evening sessions within a 24-h time cycle. Wide spread brain areas were found to exhibit diurnal variations, which may be attributed to the internal molecular systems regulated by clock genes, and the environmental factors including light-dark cycle, daily activities and homeostatic sleep drive. Notably, the diurnal variation of default mode network (DMN) suggests that there is an adaptation or compensation response within the subregions of DMN, implying a balance or a decoupling of regulation between these regions.
关于人类大脑中神经活动如何随昼夜节律变化仍在进行研究。静息态功能磁共振成像（RS-fMRI）反映了人类大脑的自发活动和/或内源性神经生理过程。在本研究中，我们基于RS-fMRI应用局部一致性（ReHo）和低频振幅（ALFF）来探索在24小时时间周期内上午和晚上时段全脑自发脑活动的区域差异。发现广泛的脑区存在昼夜变化，这可能归因于由生物钟基因调节的内部分子系统以及包括明暗周期、日常活动和稳态睡眠驱动力在内的环境因素。值得注意的是，默认模式网络（DMN）的昼夜变化表明在DMN的子区域内存在一种适应或补偿反应，这意味着这些区域之间调节的平衡或解耦。
