Whittaker John H, Robertson Alan P, Kimber Michael J, Day Tim A, Carlson Steve A
Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
J Bacteriol Parasitol. 2016 Oct;7(5). doi: 10.4172/2155-9597.1000294. Epub 2016 Oct 31.
The objective of this study was to investigate an interaction between nematodes and gut Enterobacteriaceae that use benzimidazoles as a carbon source. By addressing this objective, we identified an anthelmintic resistance-like mechanism for gastrointestinal nematodes. We isolated 30 gut bacteria (family Enterobacteriaceae) that subsist on and putatively catabolize benzimidazole-class anthelmintics. was protected from the effects of benzimidazoles when co-incubated with these Enterobacteriaceae that also protect adult ascarids from the effects of albendazole. This bacterial phenotype represents a novel mechanism by which gastrointestinal nematodes are potentially spared from the effects of benzimidazoles, without any apparent fitness cost to the parasite.
本研究的目的是调查线虫与以苯并咪唑作为碳源的肠道肠杆菌科细菌之间的相互作用。通过实现这一目标，我们确定了一种针对胃肠道线虫的抗驱虫药样机制。我们分离出30种肠道细菌（肠杆菌科），它们以苯并咪唑类驱虫药为食并可能对其进行分解代谢。当与这些肠杆菌科细菌共同孵育时，[此处原文缺失主语]受到保护，免受苯并咪唑的影响，这些细菌也能保护成虫蛔虫免受阿苯达唑的影响。这种细菌表型代表了一种新机制，通过该机制胃肠道线虫可能免受苯并咪唑的影响，而对寄生虫没有任何明显的适应性代价。
