Gerbaba Teklu K, Green-Harrison Luke, Buret Andre G
Department of Medicine, Queen's University, Kingston, ON, Canada.
Department of Biological Sciences, University of Calgary, Calgary, AB, Canada.
J Nematol. 2017 Dec;49(4):348-356.
The microbiome influences host processes including nutritional availability, development, immunity, and behavioral responses. is a powerful model to study molecular mechanisms of host-microbial interactions. Recent efforts have been made to profile the natural microbiome of , laying a foundation for mechanistic studies of host-microbiome interactions in this genetically tractable model system. Studies using single-species microbes, multi-microbial systems, and humanized worm-microbiome interaction studies reveal metabolic and microbial-microbial interactions relevant in higher organisms. This article discusses recent developments in modeling the effects of host-microbiome interactions in .
微生物组影响宿主的多种生理过程，包括营养供应、发育、免疫和行为反应。它是研究宿主-微生物相互作用分子机制的有力模型。最近已开展工作来描绘其天然微生物组，为在这个具有遗传易处理性的模型系统中进行宿主-微生物组相互作用的机制研究奠定了基础。使用单物种微生物、多微生物系统以及人源化线虫-微生物组相互作用研究的结果揭示了在高等生物中相关的代谢和微生物-微生物相互作用。本文讨论了在线虫中模拟宿主-微生物组相互作用效应方面的最新进展。
