Liao Zhen-Lin, Zeng Ben-Hua, Wang Wei, Li Gui-Hua, Wu Fei, Wang Li, Zhong Qing-Ping, Wei Hong, Fang Xiang
College of Food Science, South China Agricultural University , Guangzhou , China.
Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University , Chongqing , China.
Front Nutr. 2016 Dec 21;3:42. doi: 10.3389/fnut.2016.00042. eCollection 2016.
There is an increasing interest in the effect of dietary polyphenols on the intestinal microbiota and the possible associations between this effect and the development of some cardiovascular diseases, such as atherosclerosis (AS). However, limited information is available on how these polyphenols affect the gut microbiota and AS development. This study was designed to evaluate the modulation of dietary tea polyphenols (TPs) on intestinal (IB) and its correlation with AS development in apolipoprotein E-deficient (ApoE) mice. Fifty C57BL/6 ApoE mice were randomized into one of the five treatment groups ( = 10/group): control group fed normal diet (CK); a group fed a high-fat diet (HFD); and the other three groups fed the same HFD supplemented with TPs in drinking water for 16 weeks. The total cholesterol and low-density lipoprotein cholesterol (LDL-C) were decreased significantly ( < 0.05) after TP interference. In addition, the TP diet also decreased the plaque area/lumen area (PA/LA) ratios ( < 0.01) in the TP diet group. Interestingly, copies of IB in the gut of ApoE mice were notably increased with TP interference. This increase was dose dependent ( < 0.01) and negatively correlated with the PA/LA ratio ( < 0.05). We conclude that TPs could promote the proliferation of the IB, which is partially responsible for the reduction of AS plaque induced by HFD.
饮食中多酚对肠道微生物群的影响以及这种影响与某些心血管疾病（如动脉粥样硬化，AS）发展之间的可能关联，正受到越来越多的关注。然而，关于这些多酚如何影响肠道微生物群和AS发展的信息有限。本研究旨在评估饮食中茶多酚（TPs）对肠道菌群（IB）的调节作用及其与载脂蛋白E缺陷（ApoE）小鼠AS发展的相关性。50只C57BL/6 ApoE小鼠被随机分为五个治疗组之一（每组n = 10）：喂食正常饮食的对照组（CK）；喂食高脂饮食（HFD）的组；以及其他三组在饮用水中添加TPs并喂食相同HFD 16周的组。TP干预后，总胆固醇和低密度脂蛋白胆固醇（LDL-C）显著降低（P < 0.05）。此外，TP饮食组的斑块面积/管腔面积（PA/LA）比值也降低（P < 0.01）。有趣的是，ApoE小鼠肠道中的IB拷贝数在TP干预后显著增加。这种增加呈剂量依赖性（P < 0.01），且与PA/LA比值呈负相关（P < 0.05）。我们得出结论，TPs可促进IB的增殖，这部分解释了HFD诱导的AS斑块减少的原因。
