Guo Xiaoning, Li Xiaoyang, Liu Tang, Shuai Cijun, Zhang Qing
Department of Orthopaedics, the Second Xiangya hospital, Central South University, 139 Renmin road, Changsha, 410011, People's Republic of China.
Orthopedic Biomedical Materials Institute, Central South University, Changsha, 410083, People's Republic of China.
World J Surg Oncol. 2017 Jan 9;15(1):13. doi: 10.1186/s12957-016-1065-4.
The treatment of periacetabular malignant bone tumours is challenging. Many methods of reconstruction after internal hemipelvectomy have been reported and each method has its own limitations. The aim of this study was to evaluate the oncological and functional outcomes of pasteurized autograft reconstruction after resection of periacetabular malignant bone tumours.
Ten patients (six male, four female) with periacetabular malignant tumours, who underwent resection and reconstruction with pasteurized autograft, were retrospectively reviewed. The patients' average age at diagnosis was 40 years (range 13-65 years). There were five patients with chondrosarcoma, three with osteosarcoma, one with Ewing's sarcoma, and one with solitary metastatic thyroid carcinoma.
At the last follow-up, seven patients were alive (six with no evidence of the primary disease and one with lung metastasis for 5 months). The three other patients died of metastasis of the primary disease with a mean survival time of 12 (range 8-17) months postoperatively. The mean follow-up time for all patients was 45 (range 8-87) months. Local recurrence rate was 10%. The mean time of bone union was 12 (range 6-21) months after the operation. The mean Musculoskeletal Tumor Society score for all living patients at the last follow-up was 70.5% (range 43.3-86.7%).
Reconstruction with pasteurized autograft is a feasible method for treating periacetabular malignant bone tumours, with satisfactory oncological and functional outcomes and a relatively low incidence of complications.
髋臼周围恶性骨肿瘤的治疗具有挑战性。已报道了许多半骨盆内切除术后的重建方法，且每种方法都有其自身的局限性。本研究的目的是评估髋臼周围恶性骨肿瘤切除术后经巴氏消毒的自体骨移植重建的肿瘤学和功能结果。
回顾性分析10例接受经巴氏消毒自体骨移植切除和重建的髋臼周围恶性肿瘤患者（6例男性，4例女性）。患者诊断时的平均年龄为40岁（范围13 - 65岁）。其中5例为软骨肉瘤，3例为骨肉瘤，1例为尤因肉瘤，1例为孤立性甲状腺癌肺转移。
在最后一次随访时，7例患者存活（6例无原发疾病证据，1例肺转移5个月）。其他3例患者死于原发疾病转移，术后平均生存时间为12（范围8 - 17）个月。所有患者的平均随访时间为45（范围8 - 87）个月。局部复发率为10%。术后骨愈合的平均时间为12（范围6 - 21）个月。最后一次随访时所有存活患者的肌肉骨骼肿瘤学会平均评分为70.5%（范围43.3 - 86.7%）。
经巴氏消毒自体骨移植重建是治疗髋臼周围恶性骨肿瘤的一种可行方法，具有满意的肿瘤学和功能结果，且并发症发生率相对较低。
