越南乳腺癌风险因素的配对病例对照研究。
A Matched Case-Control Study of Risk Factors for Breast Cancer Risk in Vietnam.
作者信息
Nguyen J, Le Q H, Duong B H, Sun P, Pham H T, Ta V T, Kotsopoulos J, Narod S A, Ginsburg O
机构信息
Queen's University, Kingston, ON, Canada; Lakeridge Health, Oshawa, ON, Canada.
Hospital K, National Cancer Hospital of Vietnam, Hanoi, Vietnam.
出版信息
Int J Breast Cancer. 2016;2016:7164623. doi: 10.1155/2016/7164623. Epub 2016 Dec 13.
. Vietnam has a low age-standardized incidence of breast cancer, but the incidence is rising rapidly with economic development. We report data from a matched case-control study of risk factors for breast cancer in the largest cancer hospital in Vietnam. . 492 incident breast cancer cases unselected for family history or age at diagnosis and 1306 control women age 25-75 were recruited from the National Cancer Hospital (BVK), Hanoi. Structured interviews were conducted and pathology data was centrally reported at the National Cancer Hospital of Vietnam, in Hanoi. . Our analysis included 294 matched pairs. Mean age at diagnosis was 46.7 years. Lower mean parity, older age at first parity, increasing weight and BMI at age 18, and increasing BMI at diagnosis were positively correlated with breast cancer cases compared to controls. Age at first menarche and duration of breastfeeding were not statistically different between cases and controls. . In this study we demonstrate that breast cancer in Vietnam is associated with some but not all of the published risk factors from Western populations. Our data is consistent with other studies of breast cancer in Asian populations.
越南乳腺癌的年龄标准化发病率较低，但随着经济发展，发病率正在迅速上升。我们报告了越南最大的癌症医院进行的一项关于乳腺癌危险因素的配对病例对照研究的数据。从河内的国家癌症医院（BVK）招募了492例未经家族史或诊断年龄筛选的乳腺癌新发病例以及1306名年龄在25至75岁之间的对照女性。进行了结构化访谈，病理数据在河内的越南国家癌症医院集中报告。我们的分析包括294对匹配病例。诊断时的平均年龄为46.7岁。与对照组相比，较低的平均产次、初产年龄较大、18岁时体重和体重指数增加以及诊断时体重指数增加与乳腺癌病例呈正相关。病例组和对照组的初潮年龄和母乳喂养持续时间在统计学上无差异。在本研究中，我们证明越南的乳腺癌与西方人群中已公布的部分而非全部危险因素相关。我们的数据与亚洲人群乳腺癌的其他研究结果一致。
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