长链非编码RNA与微小RNA：前列腺癌的潜在生物标志物和治疗靶点
LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer.
作者信息
Ma Guoxing, Tang Mingqing, Wu Yaqing, Xu Xiaoming, Pan Feng, Xu Ruian
机构信息
Engineering Research Center of Molecular Medicine, Ministry of Education, China & School of Biomedical Sciences, Huaqiao UniversityXiamen, China; Key Laboratory of Xiamen Marine and Gene DrugsXiamen, China; Key Laboratory of Fujian Molecular MedicineXiamen 361021, China.
Engineering Research Center of Molecular Medicine, Ministry of Education, China & School of Biomedical Sciences, Huaqiao UniversityXiamen, China; Key Laboratory of Fujian Molecular MedicineXiamen 361021, China.
出版信息
Am J Transl Res. 2016 Dec 15;8(12):5141-5150. eCollection 2016.
Abstract
Prostate cancer (PCa) is the second lethal disease for men in western countries. Although androgen receptor (AR) signaling has been widely investigated, noncoding RNAs (ncRNAs), deficient of open reading frame, have also received considerable attention. Growing studies showed that the aberrant ncRNAs expression contributed to cell proliferation, metastasis and drug resistance in PCa. Therefore, therapeutically targeting ncRNAs may synergize androgen deprivation therapy (ADT) to have a better effect to fight against PCa, especially castration-resistant prostate cancer (CRPC). This review would systematically summarize the multicellular events controlled by ncRNAs and give a snapshot of future scientific activities and clinical applications.
摘要
前列腺癌（PCa）是西方国家男性的第二大致死性疾病。尽管雄激素受体（AR）信号通路已得到广泛研究，但缺乏开放阅读框的非编码RNA（ncRNAs）也受到了相当多的关注。越来越多的研究表明，ncRNAs的异常表达促进了PCa中的细胞增殖、转移和耐药性。因此，以ncRNAs为治疗靶点可能会与雄激素剥夺疗法（ADT）协同作用，从而在对抗PCa，尤其是去势抵抗性前列腺癌（CRPC）方面产生更好的效果。本综述将系统地总结由ncRNAs控制的多细胞事件，并简要介绍未来的科学活动和临床应用。
相似文献
1
LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer.长链非编码RNA与微小RNA：前列腺癌的潜在生物标志物和治疗靶点
Am J Transl Res. 2016 Dec 15;8(12):5141-5150. eCollection 2016.
2
Androgen Receptor-Related Non-coding RNAs in Prostate Cancer.前列腺癌中与雄激素受体相关的非编码RNA
Front Cell Dev Biol. 2021 Apr 1;9:660853. doi: 10.3389/fcell.2021.660853. eCollection 2021.
3
, , and : Novel Potential Biomarkers and Therapeutic Targets in Castration-Resistant Prostate Cancer.去势抵抗性前列腺癌的新型潜在生物标志物和治疗靶点。
Int J Mol Sci. 2019 Jun 8;20(11):2802. doi: 10.3390/ijms20112802.
4
Androgen receptors in hormone-dependent and castration-resistant prostate cancer.雄激素受体在激素依赖性和去势抵抗性前列腺癌中的作用。
Pharmacol Ther. 2013 Dec;140(3):223-38. doi: 10.1016/j.pharmthera.2013.07.003. Epub 2013 Jul 13.
5
The emerging role of noncoding RNA in prostate cancer progression and its implication on diagnosis and treatment.非编码RNA在前列腺癌进展中的新作用及其对诊断和治疗的意义。
Brief Funct Genomics. 2016 May;15(3):257-65. doi: 10.1093/bfgp/elv057. Epub 2015 Dec 17.
6
Transcript Levels of Androgen Receptor Variant 7 and Ubiquitin-Conjugating Enzyme 2C in Hormone Sensitive Prostate Cancer and Castration-Resistant Prostate Cancer.激素敏感性前列腺癌和去势抵抗性前列腺癌中雄激素受体变异体7和泛素结合酶2C的转录水平
Prostate. 2017 Jan;77(1):60-71. doi: 10.1002/pros.23248. Epub 2016 Aug 22.
7
lncRNA HOXD-AS1 Regulates Proliferation and Chemo-Resistance of Castration-Resistant Prostate Cancer via Recruiting WDR5.长链非编码RNA HOXD-AS1通过招募WDR5调控去势抵抗性前列腺癌的增殖和化疗耐药性。
Mol Ther. 2017 Aug 2;25(8):1959-1973. doi: 10.1016/j.ymthe.2017.04.016. Epub 2017 May 6.
8
The long noncoding RNA HORAS5 mediates castration-resistant prostate cancer survival by activating the androgen receptor transcriptional program.长链非编码 RNA HORAS5 通过激活雄激素受体转录程序介导去势抵抗性前列腺癌的存活。
Mol Oncol. 2019 May;13(5):1121-1136. doi: 10.1002/1878-0261.12471. Epub 2019 Mar 5.
9
Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model.在原位VCaP人前列腺癌异种移植模型中，去势诱导瘤内雄激素生物合成及雄激素受体表达上调。
Am J Pathol. 2014 Aug;184(8):2163-73. doi: 10.1016/j.ajpath.2014.04.010. Epub 2014 Jun 17.
10
A novel AR translational regulator lncRNA LBCS inhibits castration resistance of prostate cancer.一种新型 AR 翻译调节长链非编码 RNA LBCS 抑制前列腺癌去势抵抗。
Mol Cancer. 2019 Jun 20;18(1):109. doi: 10.1186/s12943-019-1037-8.
引用本文的文献
1
Long non-coding RNAs: regulators of autophagy and potential biomarkers in therapy resistance and urological cancers.长链非编码RNA：自噬的调节因子以及治疗耐药性和泌尿系统癌症中的潜在生物标志物。
Front Pharmacol. 2024 Oct 24;15:1442227. doi: 10.3389/fphar.2024.1442227. eCollection 2024.
2
The inhibition effect of psoralen on prostate cancer PC3 cells via down-regulation of long non-coding RNA ENST00000510619.补骨脂素通过下调长链非编码RNA ENST00000510619对前列腺癌PC3细胞的抑制作用。
Transl Androl Urol. 2024 Oct 31;13(10):2294-2306. doi: 10.21037/tau-24-457. Epub 2024 Oct 28.
3
The Role of SNHG15 in the Pathogenesis of Hepatocellular Carcinoma.SNHG15在肝细胞癌发病机制中的作用
J Pers Med. 2022 May 6;12(5):753. doi: 10.3390/jpm12050753.
4
Heterogeneous graph inference based on similarity network fusion for predicting lncRNA-miRNA interaction.基于相似性网络融合的异质图推理用于预测长链非编码RNA-微小RNA相互作用
RSC Adv. 2020 Mar 23;10(20):11634-11642. doi: 10.1039/c9ra11043g. eCollection 2020 Mar 19.
5
The Crosstalk of Long Non-Coding RNA and MicroRNA in Castration-Resistant and Neuroendocrine Prostate Cancer: Their Interaction and Clinical Importance.长链非编码 RNA 与 microRNA 在去势抵抗性和神经内分泌前列腺癌中的串扰：它们的相互作用和临床意义。
Int J Mol Sci. 2021 Dec 30;23(1):392. doi: 10.3390/ijms23010392.
6
Role of miR-182/PDCD4 axis in aggressive behavior of prostate cancer in the African Americans.miR-182/PDCD4轴在非裔美国人前列腺癌侵袭性中的作用
BMC Cancer. 2021 Sep 15;21(1):1028. doi: 10.1186/s12885-021-08723-6.
7
Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis.环状 RNA circRNA_101996 通过调控 miR-1236-3p/TRIM37 轴促进宫颈癌的发展。
Kaohsiung J Med Sci. 2021 Jul;37(7):547-561. doi: 10.1002/kjm2.12378. Epub 2021 Mar 17.
8
MicroRNAs in treatment-induced neuroendocrine differentiation in prostate cancer.微小RNA在前列腺癌治疗诱导的神经内分泌分化中的作用
Cancer Drug Resist. 2020;3(4):804-818. doi: 10.20517/cdr.2020.30. Epub 2020 Oct 12.
9
LncRNA PCAT-1 upregulates RAP1A through modulating miR-324-5p and promotes survival in lung cancer.长链非编码RNA PCAT-1通过调控miR-324-5p上调RAP1A并促进肺癌细胞存活。
Arch Med Sci. 2019 Apr 5;16(5):1196-1206. doi: 10.5114/aoms.2019.84235. eCollection 2020.
10
Hsa_circRNA_102002 facilitates metastasis of papillary thyroid cancer through regulating miR-488-3p/HAS2 axis.hsa_circRNA_102002 通过调控 miR-488-3p/HAS2 轴促进甲状腺乳头状癌细胞的转移。
Cancer Gene Ther. 2021 Apr;28(3-4):279-293. doi: 10.1038/s41417-020-00218-z. Epub 2020 Aug 29.
本文引用的文献
1
MALAT1 is an oncogenic long non-coding RNA associated with tumor invasion in non-small cell lung cancer regulated by DNA methylation.MALAT1是一种致癌性长链非编码RNA，与DNA甲基化调控的非小细胞肺癌中的肿瘤侵袭相关。
Int J Clin Exp Pathol. 2015 Dec 1;8(12):15903-10. eCollection 2015.
2
miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src.miR-124与雄激素受体信号抑制剂通过下调雄激素受体剪接变体、EZH2和Src来抑制前列腺癌生长。
Cancer Res. 2015 Dec 15;75(24):5309-17. doi: 10.1158/0008-5472.CAN-14-0795. Epub 2015 Nov 16.
3
LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer.长链非编码RNA MALAT1增强了去势抵抗性前列腺癌中EZH2的致癌活性。
Oncotarget. 2015 Dec 1;6(38):41045-55. doi: 10.18632/oncotarget.5728.
4
A basal stem cell signature identifies aggressive prostate cancer phenotypes.一种基底干细胞特征可识别侵袭性前列腺癌表型。
Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6544-52. doi: 10.1073/pnas.1518007112. Epub 2015 Oct 12.
5
MicroRNA in prostate cancer.前列腺癌中的微小RNA
Clin Chim Acta. 2015 Dec 7;451(Pt B):154-60. doi: 10.1016/j.cca.2015.09.022. Epub 2015 Sep 28.
6
LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer.长链非编码RNA HOTAIR增强雄激素受体介导的转录程序并驱动去势抵抗性前列腺癌。
Cell Rep. 2015 Oct 6;13(1):209-221. doi: 10.1016/j.celrep.2015.08.069. Epub 2015 Sep 24.
7
Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2α/androgen receptor signals.浸润性骨髓间充质干细胞（BM-MSCs）通过改变CCL5/HIF2α/雄激素受体信号增强前列腺癌细胞的侵袭能力。
Oncotarget. 2015 Sep 29;6(29):27555-65. doi: 10.18632/oncotarget.4515.
8
Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer.长链非编码RNA MALAT1的下调通过PI3K-AKT途径诱导乳腺癌上皮-间质转化。
Int J Clin Exp Pathol. 2015 May 1;8(5):4881-91. eCollection 2015.
9
A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature.一种长链非编码RNA通过建立剪接特异性染色质特征来调控可变剪接。
Nat Struct Mol Biol. 2015 May;22(5):370-6. doi: 10.1038/nsmb.3005. Epub 2015 Apr 6.
10
The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo.长链非编码RNA PCGEM1在体内受雄激素受体活性调控。
Mol Cancer. 2015 Feb 21;14:46. doi: 10.1186/s12943-015-0314-4.
Zotero 插件