Kim Justine S, Kaminsky Alexander J, Summitt J Blair, Thayer Wesley P
Vanderbilt University Hospital , Nashville, Tennessee.
Inova Fairfax Hospital , Falls Church, Virginia.
Adv Wound Care (New Rochelle). 2016 Dec 1;5(12):546-552. doi: 10.1089/wound.2015.0681.
Burn injuries remain a large financial burden on the healthcare system. According to CDC statistics (2010), nonfatal and hospitalized burns in the U.S. cost $1.8 billion for an annual incidence of ∼486,000 cases. To date, no technique proves to be the ideal therapy of deep partial-thickness burns. In this study, we review a trial usage of ACell (ACell, Inc.) wound matrix on deep partial-thickness burns. Burn patients were admitted through the Vanderbilt Emergency Department. Three were consented to receive ACell therapy. Each patient suffered extremity burns, to which ACell MatriStem matrix was applied. Time to epithelialization and healing was monitored up to 1 month postintervention. ACell MatriStem matrix use in deep partial-thickness burns enabled healing by 29 days on average without requiring autografts. The average total body surface area (TBSA) of injury was 7.2% with average TBSA treated with ACell equal to 2.5%. All burn sites underwent re-epithelialization after 5.6 days on average (range 4-7 days). Average length of stay after ACell placement totaled 2 days. All patients fully healed without the need for subsequent grafting or contracture development. No postoperative complications were noted. To the extent of our knowledge, this is one of the first reported series to utilize ACell MatriStem product in deep partial-thickness extremity burns. Despite numerous products currently available for burn reconstruction, no one product embodies all the characteristics of an ideal graft. ACell biological extracellular matrix scaffolding appears promising, allowing for healing without use of an autograft.
烧伤仍然给医疗系统带来巨大的经济负担。根据美国疾病控制与预防中心（CDC）2010年的统计数据，美国非致命性且需住院治疗的烧伤病例每年约48.6万例，花费达18亿美元。迄今为止，尚无技术被证明是治疗深二度烧伤的理想疗法。在本研究中，我们回顾了ACell公司的伤口基质在深二度烧伤治疗中的试用情况。烧伤患者通过范德比尔特急诊部入院。三名患者同意接受ACell治疗。每位患者均为四肢烧伤，并应用了ACell MatriStem基质。干预后长达1个月的时间里，对上皮化和愈合时间进行了监测。在深二度烧伤中使用ACell MatriStem基质平均29天即可实现愈合，无需自体移植。平均全身烧伤面积（TBSA）为7.2%，接受ACell治疗的平均TBSA为2.5%。所有烧伤部位平均在5.6天（范围为4 - 7天）后实现再上皮化。放置ACell后的平均住院时间总计2天。所有患者均完全愈合，无需后续移植或出现挛缩。未观察到术后并发症。就我们所知，这是首批报道的在深二度四肢烧伤中使用ACell MatriStem产品的系列研究之一。尽管目前有众多产品可用于烧伤重建，但没有一种产品具备理想移植物的所有特性。ACell生物细胞外基质支架似乎很有前景，可实现无需自体移植的愈合。
