用于生物医学应用的将超分子外功能化钯笼与肽偶联的生物共轭策略。
Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications.
作者信息
Han J, Schmidt A, Zhang T, Permentier H, Groothuis G M M, Bischoff R, Kühn F E, Horvatovich P, Casini A
机构信息
Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Molecular Catalysis, Catalysis Research Center and Department of Chemistry, Technische Universität München, Lichtenbergstr. 4, 85747 Garching bei München, Germany.
出版信息
Chem Commun (Camb). 2017 Jan 24;53(8):1405-1408. doi: 10.1039/c6cc08937b.
Supramolecular PdL cages (L = ligand) hold promise as drug delivery systems. With the idea of achieving targeted delivery of the metallacages to tumor cells, the bioconjugation of exo-functionalized self-assembled PdL cages to peptides following two different approaches is reported for the first time. The obtained bioconjugates were analyzed and identified by high-resolution mass spectrometry.
超分子钯配体笼（L = 配体）有望成为药物递送系统。为了实现金属笼向肿瘤细胞的靶向递送，首次报道了通过两种不同方法将外官能化自组装钯配体笼与肽进行生物共轭。通过高分辨率质谱对所得生物共轭物进行了分析和鉴定。
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