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大鼠模型中使用工程化多层心肌补片进行全层心脏修复

Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model.

作者信息

Pok Seokwon, Stupin Igor V, Tsao Christopher, Pautler Robia G, Gao Yang, Nieto Raymond M, Tao Ze-Wei, Fraser Charles D, Annapragada Ananth V, Jacot Jeffrey G

机构信息

Department of Bioengineering, Rice University, Houston, TX 77005, USA.

Division of Congenital Heart Surgery, Texas Children's Hospital, Houston, TX 77030, USA.

出版信息

Adv Healthc Mater. 2017 Mar;6(5). doi: 10.1002/adhm.201600549. Epub 2017 Jan 12.

DOI:10.1002/adhm.201600549
PMID:28081298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5896558/
Abstract

In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch.

摘要

在右游离壁置换的大鼠模型中，与使用市售心包补片相比，移植由聚己内酯膜支撑壳聚糖/心脏基质水凝胶制成的工程化多层心肌补片可诱导显著的肌肉和血管重塑，并导致右心室射血分数显著更高。

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本文引用的文献

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Use of extracellular matrix patches in cardiac surgery.细胞外基质贴片在心脏手术中的应用。
J Card Surg. 2015 Feb;30(2):145-8. doi: 10.1111/jocs.12494. Epub 2014 Dec 23.
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Heart disease and stroke statistics--2015 update: a report from the American Heart Association.《2015年心脏病和中风统计数据更新：美国心脏协会报告》
Circulation. 2015 Jan 27;131(4):e29-322. doi: 10.1161/CIR.0000000000000152. Epub 2014 Dec 17.
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Bacterial nanocellulose as a new patch material for closure of ventricular septal defects in a pig model.细菌纳米纤维素作为一种用于猪模型室间隔缺损封堵的新型贴片材料。
Eur J Cardiothorac Surg. 2015 Jun;47(6):1013-21. doi: 10.1093/ejcts/ezu292. Epub 2014 Jul 26.
4
Use of myocardial matrix in a chitosan-based full-thickness heart patch.心肌基质在基于壳聚糖的全层心脏补片中的应用。
Tissue Eng Part A. 2014 Jul;20(13-14):1877-87. doi: 10.1089/ten.TEA.2013.0620. Epub 2014 Feb 24.
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Urinary bladder matrix promotes site appropriate tissue formation following right ventricle outflow tract repair.尿路上皮基质促进右心室流出道修复后合适部位的组织形成。
Organogenesis. 2013 Jul-Sep;9(3):149-60. doi: 10.4161/org.25394. Epub 2013 Jun 25.
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Evaluation of a tissue-engineered bovine pericardial patch in paediatric patients with congenital cardiac anomalies: initial experience with the ADAPT-treated CardioCel(R) patch.组织工程化牛心包补片在先天性心脏畸形小儿患者中的评估：ADAPT 治疗的 CardioCel(R) 补片的初步经验
Interact Cardiovasc Thorac Surg. 2013 Oct;17(4):698-702. doi: 10.1093/icvts/ivt268. Epub 2013 Jul 6.
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Stability and mechanical evaluation of bovine pericardium cross-linked with polyurethane prepolymer in aqueous medium.在水介质中用聚氨酯预聚物交联牛心包的稳定性和力学评价。
Mater Sci Eng C Mater Biol Appl. 2013 May 1;33(4):2392-8. doi: 10.1016/j.msec.2013.02.001. Epub 2013 Feb 8.
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A multilayered scaffold of a chitosan and gelatin hydrogel supported by a PCL core for cardiac tissue engineering.用于心脏组织工程的壳聚糖和明胶水凝胶多层支架，由 PCL 芯支撑。
Acta Biomater. 2013 Mar;9(3):5630-42. doi: 10.1016/j.actbio.2012.10.032. Epub 2012 Nov 2.
9
Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials.巨噬细胞表型作为生物衍生外科网片材料植入后建设性重塑的预测因子。
Acta Biomater. 2012 Mar;8(3):978-87. doi: 10.1016/j.actbio.2011.11.031. Epub 2011 Dec 2.
10
Current usage and future directions for the bovine pericardial patch.牛心包补片的当前应用及未来发展方向。
Ann Vasc Surg. 2011 May;25(4):561-8. doi: 10.1016/j.avsg.2010.11.007. Epub 2011 Jan 28.