基于 ESIPT 的用于水溶液中肼检测的荧光探针及其在活细胞中的应用。
An ESIPT-Based Fluorescent Probe for Hydrazine Detection in Aqueous Solution and its Application in Living Cells.
机构信息
College of Chemistry and Chemical Engineering, Xuchang University, Xuchang, 461000, China.
Institute of Quality Standards and Testing Technology for Agro-Products, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China.
出版信息
J Fluoresc. 2017 Mar;27(2):679-687. doi: 10.1007/s10895-016-1997-7. Epub 2017 Jan 13.
A new fluorescent probe based on "protection-deprotection" sequence and the excited-state intramolecular proton transfer (ESIPT) effect was designed and synthesized. The probe responds rapidly and high selectively toward hydrazine at room temperature, and exhibits a low detection limit of 0.016 μM (0.512 ppb), which is well below the safety level (10 ppb) as regulated by EPA. Moreover, it can be applied for the imaging of hydrazine in living cells.
一种基于“保护-脱保护”序列和激发态分子内质子转移（ESIPT）效应的新型荧光探针被设计和合成。该探针在室温下对水合肼快速且高选择性地响应，并表现出低检测限为 0.016 μM（0.512 ppb），远低于 EPA 规定的安全水平（10 ppb）。此外，它还可以用于活细胞中水合肼的成像。
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