Genzel Lisa, Rossato Janine I, Jacobse Justin, Grieves Roddy M, Spooner Patrick A, Battaglia Francesco P, Fernández Guillen, Morris Richard G M
Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh, United Kingdom.
Institute for Behavioural Neuroscience, University College London, London, United Kingdom.
PLoS Biol. 2017 Jan 13;15(1):e2000531. doi: 10.1371/journal.pbio.2000531. eCollection 2017 Jan.
While hippocampal and cortical mechanisms of memory consolidation have long been studied, their interaction is poorly understood. We sought to investigate potential interactions with respect to trace dominance, strengthening, and interference associated with postencoding novelty or sleep. A learning procedure was scheduled in a watermaze that placed the impact of novelty and sleep in opposition. Distinct behavioural manipulations-context preexposure or interference during memory retrieval-differentially affected trace dominance and trace survival, respectively. Analysis of immediate early gene expression revealed parallel up-regulation in the hippocampus and cortex, sustained in the hippocampus in association with novelty but in the cortex in association with sleep. These findings shed light on dynamically interacting mechanisms mediating the stabilization of hippocampal and neocortical memory traces. Hippocampal memory traces followed by novelty were more dominant by default but liable to interference, whereas sleep engaged a lasting stabilization of cortical traces and consequent trace dominance after preexposure.
虽然海马体和皮层在记忆巩固中的机制早已得到研究，但它们之间的相互作用却鲜为人知。我们试图研究与编码后新奇性或睡眠相关的痕迹优势、强化和干扰方面的潜在相互作用。在水迷宫中安排了一个学习程序，使新奇性和睡眠的影响相互对立。不同的行为操作——情境预暴露或记忆检索期间的干扰——分别对痕迹优势和痕迹留存产生不同影响。对即刻早期基因表达的分析显示，海马体和皮层中出现了平行的上调，在海马体中与新奇性相关的上调持续存在，而在皮层中与睡眠相关的上调持续存在。这些发现揭示了介导海马体和新皮层记忆痕迹稳定的动态相互作用机制。随后出现新奇性的海马体记忆痕迹默认情况下更具优势，但容易受到干扰，而睡眠则在预暴露后使皮层痕迹实现持久稳定并产生相应的痕迹优势。
