Department of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas at Austin, Austin, TX, USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA.
Department of Psychology, Temple University, Philadelphia, PA, USA.
Trends Cogn Sci. 2022 Sep;26(9):782-795. doi: 10.1016/j.tics.2022.06.009. Epub 2022 Jul 13.
The long-term fate of a memory is not exclusively determined by the events occurring at the moment of encoding. Research at the cellular, circuit, and behavioral levels is beginning to reveal how neurochemical activations in the moments surrounding an event can retroactively and proactively rescue weak memory for seemingly mundane experiences. We review emerging evidence showing enhancement of weakly formed memories encoded minutes to hours before or after a related motivationally relevant experience. We discuss proposed neurobiological mechanisms for strengthening weak memories formed in temporal proximity to a strong event, and how this knowledge could be leveraged to improve memory for information that is prone to forgetting.
一段记忆的长期命运并非完全由编码时刻发生的事件决定。在细胞、回路和行为层面的研究开始揭示，事件发生前后的神经化学激活如何能回溯性和前瞻性地挽救对看似平凡经历的微弱记忆。我们综述了新兴的证据，这些证据表明，在相关动机相关体验之前或之后几分钟到几小时内编码的弱记忆可以得到增强。我们讨论了增强在与强事件时间接近时形成的弱记忆的神经生物学机制，以及如何利用这些知识来改善容易遗忘的信息的记忆。
