Creel Liza M, Gregory Sean, McNeal Catherine J, Beeram Madhava R, Krauss David R
Department of Health Management and Systems Science, School of Public Health & Information Sciences, University of Louisville, Louisville, USA.
Department of Health Policy and Management, College of Public Health, University of South Florida, 13201 Bruce B Downs Blvd, MDC 56, Tampa, FL, 33616, USA.
BMC Res Notes. 2017 Jan 13;10(1):42. doi: 10.1186/s13104-016-2336-4.
In the US, approximately 12.7% of all live births are preterm, 8.2% of live births were low birth weight (LBW), and 1.5% are very low birth weight (VLBW). Although technological advances have improved mortality rates among preterm and LBW infants, improving overall rates of prematurity and LBW remains a national priority. Monitoring short- and long-term outcomes is critical for advancing medical treatment and minimizing morbidities associated with prematurity or LBW; however, studying these infants can be challenging. Several large, multi-center neonatal databases have been developed to improve research and quality improvement of treatments for and outcomes of premature and LBW infants. The purpose of this systematic review was to describe three multi-center neonatal databases.
We conducted a literature search using PubMed and Google Scholar over the period 1990 to August 2014. Studies were included in our review if one of the databases was used as a primary source of data or comparison. Included studies were categorized by year of publication; study design employed, and research focus.
A total of 343 studies published between 1991 and 2014 were included. Studies of premature and LBW infants using these databases have increased over time, and provide evidence for both neonatology and community-based pediatric practice.
Research into treatment and outcomes of premature and LBW infants is expanding, partially due to the availability of large, multicenter databases. The consistency of clinical conditions and neonatal outcomes studied since 1990 demonstrates that there are dedicated research agendas and resources that allow for long-term, and potentially replicable, studies within this population.
在美国，所有活产婴儿中约12.7%为早产，8.2%为低出生体重儿，1.5%为极低出生体重儿。尽管技术进步提高了早产和低出生体重儿的死亡率，但提高早产和低出生体重的总体发生率仍是国家优先事项。监测短期和长期结局对于推进医学治疗和将与早产或低出生体重相关的发病率降至最低至关重要；然而，研究这些婴儿可能具有挑战性。已经建立了几个大型多中心新生儿数据库，以改善对早产和低出生体重儿的治疗研究及质量改进。本系统评价的目的是描述三个多中心新生儿数据库。
我们在1990年至2014年8月期间使用PubMed和谷歌学术进行了文献检索。如果其中一个数据库被用作数据的主要来源或比较对象，则将这些研究纳入我们的评价。纳入的研究按发表年份、采用的研究设计和研究重点进行分类。
共纳入了1991年至2014年发表的343项研究。使用这些数据库对早产和低出生体重儿进行的研究随着时间的推移有所增加，并为新生儿学和社区儿科实践提供了证据。
对早产和低出生体重儿的治疗及结局的研究正在扩大，部分原因是大型多中心数据库的可用性。自1990年以来所研究的临床情况和新生儿结局的一致性表明，有专门的研究议程和资源可用于对该人群进行长期且可能可重复的研究。
