Nurnazahiah Ali, Lua Pei Lin, Shahril Mohd Razif
Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, 21300 Kuala Nerus, Terengganu, Malaysia.
Malays J Med Sci. 2016 Nov;23(6):7-24. doi: 10.21315/mjms2016.23.6.2. Epub 2016 Dec 7.
The objective of this study was to compile and analyse existing scientific evidences reporting the effects of objectively measured physical activity on the levels of adiponectin and leptin. Articles related to the effects of objectively measured physical activity on the levels of adiponectin and leptin were searched from the Medline and PubMed databases. The search was limited to 'objectively measured' physical activity, and studies that did not objectively measure the physical activity were excluded. Only English articles were included in the search and review. A total of 18 articles encompassing 2,026 respondents met the inclusion criteria. The eligible articles included all forms of evidence (e.g., cross-sectional and intervention). Seventeen and 11 studies showed the effects of objectively measured physical activity on adiponectin and leptin, respectively. Five and four cross-sectional studies showed the effects of objectively measured physical activity on adiponectin and leptin, respectively. Two out of five studies showed a weak to moderate positive association between adiponectin and objectively measured physical activity, while three out of four studies showed a weak to moderate inverse association between leptin and objectively measured physical activity. For intervention studies, six out of 12 studies involving adiponectin and five out of seven studies involving leptin showed a significant effect between the proteins and objectively measured physical activity. However, a definitive conclusion could not be drawn due to several methodological flaws in the existing articles and the acute lack of additional research in this area. In conclusion, the existing evidences are encouraging but yet not compelling. Hence, further well-designed large trials are needed before the effectiveness of objectively measured physical activity in elevating adiponectin levels and in decreasing leptin levels could be strongly confirmed.
本研究的目的是汇编和分析现有科学证据，这些证据报告了客观测量的身体活动对脂联素和瘦素水平的影响。从Medline和PubMed数据库中检索了与客观测量的身体活动对脂联素和瘦素水平影响相关的文章。检索仅限于“客观测量”的身体活动，未客观测量身体活动的研究被排除。搜索和综述仅纳入英文文章。共有18篇文章涵盖2026名受访者符合纳入标准。符合条件的文章包括所有形式的证据（如横断面研究和干预研究）。分别有17项和11项研究显示了客观测量的身体活动对脂联素和瘦素的影响。分别有5项和4项横断面研究显示了客观测量的身体活动对脂联素和瘦素的影响。五项研究中有两项显示脂联素与客观测量的身体活动之间存在弱至中度的正相关，而四项研究中有三项显示瘦素与客观测量的身体活动之间存在弱至中度的负相关。对于干预研究，涉及脂联素的12项研究中有6项，涉及瘦素的7项研究中有5项显示蛋白质与客观测量的身体活动之间存在显著影响。然而，由于现有文章存在若干方法学缺陷以及该领域严重缺乏额外研究，无法得出明确结论。总之，现有证据令人鼓舞但尚不确凿。因此，在能够有力证实客观测量的身体活动在提高脂联素水平和降低瘦素水平方面的有效性之前，需要进一步设计良好的大型试验。
