Coskun Hatice, Andic Fundagul, Daglıoglu Yusuf Kenan, Doran Figen, Sahin Kazım, Tunalı Candas, Kucuk Omer
a Faculty of Medicine, Department of Radiation Oncology , Cukurova University , Adana , Turkey.
b Experimental Medicine Research Center, Cukurova University , Adana , Turkey.
Nutr Cancer. 2017 Feb-Mar;69(2):319-329. doi: 10.1080/01635581.2017.1265133. Epub 2017 Jan 17.
We aimed to research whether lycopene (L) could prevent radiation-induced acute esophageal toxicity in Wistar albino rats. 60 rats were placed in five groups as follows: control, L, radiotherapy (RT), L before RT (L + RT), and L before and after RT (L + RT + L). 6 mg/kg bw/day L was administered 7 days in the L group, 7 days before RT in the L + RT group, and 7 days before and after in the L + RT + L group. 35 Gy thoracic RT was performed. Serum L levels were measured, and the esophagi were evaluated histopathologically for intraepithelial degenerative changes-necrosis, vacuole formation, inflammation, regeneration-mitosis, and subepithelial bulla formation. L levels were significantly higher in the L receiving groups. All histopathologic results were significantly worse in the RT group than in the none-RT groups. The L + RT and the L + RT + L groups had better results than the RT group. Grade 2-3 degenerative changes-necrosis and vacuole formation were significantly lesser in the L + RT and the L + RT + L groups than those in the RT group. There was a trend toward decreased subepithelial bulla formation and inflammation in the L + RT and the L + RT + L groups compared to the RT group. Regeneration-mitosis was insignificantly lesser in the L + RT and significantly fewer in the L + RT + L groups than that in the RT group.
我们旨在研究番茄红素（L）是否能预防Wistar白化大鼠辐射诱导的急性食管毒性。60只大鼠被分为以下五组：对照组、L组、放疗（RT）组、放疗前给予L组（L + RT）以及放疗前后均给予L组（L + RT + L）。L组每天按6 mg/kg体重给予L，连续7天；L + RT组在放疗前7天给予；L + RT + L组在放疗前后各7天给予。进行35 Gy的胸部放疗。检测血清L水平，并对食管进行组织病理学评估，观察上皮内退行性改变 - 坏死、空泡形成、炎症、再生 - 有丝分裂以及上皮下大疱形成情况。接受L的组中L水平显著更高。RT组的所有组织病理学结果均显著差于未接受放疗的组。L + RT组和L + RT + L组的结果优于RT组。L + RT组和L + RT + L组中2 - 3级退行性改变 - 坏死和空泡形成显著少于RT组。与RT组相比，L + RT组和L + RT + L组上皮下大疱形成和炎症有减少趋势。L + RT组再生 - 有丝分裂减少不显著，而L + RT + L组显著少于RT组。
