Rockfield Stephanie, Raffel Joseph, Mehta Radhe, Rehman Nabila, Nanjundan Meera
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Biol Chem. 2017 Aug 28;398(9):995-1007. doi: 10.1515/hsz-2016-0336.
Iron is an essential element required for many processes within the cell. Dysregulation in iron homeostasis due to iron overload is detrimental. This nutrient is postulated to contribute to the initiation of cancer; however, the mechanisms by which this occurs remain unclear. Defining how iron promotes the development of ovarian cancers from precursor lesions is essential for developing novel therapeutic strategies. In this review, we discuss (1) how iron overload conditions may initiate ovarian cancer development, (2) dysregulated iron metabolism in cancers, (3) the interplay between bacteria, iron, and cancer, and (4) chemotherapeutic strategies targeting iron metabolism in cancer patients.
铁是细胞内许多过程所必需的元素。铁过载导致铁稳态失调是有害的。这种营养素被认为与癌症的发生有关；然而，其发生机制尚不清楚。明确铁如何从前体病变促进卵巢癌的发展对于开发新的治疗策略至关重要。在这篇综述中，我们讨论了：（1）铁过载情况如何启动卵巢癌的发展；（2）癌症中铁代谢失调；（3）细菌、铁和癌症之间的相互作用；以及（4）针对癌症患者铁代谢的化疗策略。
