卵巢癌中的铁过载与铁代谢改变
Iron overload and altered iron metabolism in ovarian cancer.
作者信息
Rockfield Stephanie, Raffel Joseph, Mehta Radhe, Rehman Nabila, Nanjundan Meera
机构信息
.
出版信息
Biol Chem. 2017 Aug 28;398(9):995-1007. doi: 10.1515/hsz-2016-0336.
Abstract
Iron is an essential element required for many processes within the cell. Dysregulation in iron homeostasis due to iron overload is detrimental. This nutrient is postulated to contribute to the initiation of cancer; however, the mechanisms by which this occurs remain unclear. Defining how iron promotes the development of ovarian cancers from precursor lesions is essential for developing novel therapeutic strategies. In this review, we discuss (1) how iron overload conditions may initiate ovarian cancer development, (2) dysregulated iron metabolism in cancers, (3) the interplay between bacteria, iron, and cancer, and (4) chemotherapeutic strategies targeting iron metabolism in cancer patients.
摘要
铁是细胞内许多过程所必需的元素。铁过载导致铁稳态失调是有害的。这种营养素被认为与癌症的发生有关；然而，其发生机制尚不清楚。明确铁如何从前体病变促进卵巢癌的发展对于开发新的治疗策略至关重要。在这篇综述中，我们讨论了：（1）铁过载情况如何启动卵巢癌的发展；（2）癌症中铁代谢失调；（3）细菌、铁和癌症之间的相互作用；以及（4）针对癌症患者铁代谢的化疗策略。
相似文献
1
Iron overload and altered iron metabolism in ovarian cancer.卵巢癌中的铁过载与铁代谢改变
Biol Chem. 2017 Aug 28;398(9):995-1007. doi: 10.1515/hsz-2016-0336.
2
Potential involvement of iron in the pathogenesis of peritoneal endometriosis.铁在腹膜型子宫内膜异位症发病机制中的潜在作用。
Mol Hum Reprod. 2008 Jul;14(7):377-85. doi: 10.1093/molehr/gan033. Epub 2008 May 28.
3
Role of iron overload-induced macrophage apoptosis in the pathogenesis of peritoneal endometriosis.铁过载诱导的巨噬细胞凋亡在腹膜子宫内膜异位症发病机制中的作用
Reproduction. 2014 Jun;147(6):R199-207. doi: 10.1530/REP-13-0552. Epub 2014 Mar 5.
4
Fluoride-induced iron overload contributes to hepatic oxidative damage in mouse and the protective role of Grape seed proanthocyanidin extract.氟诱导的铁过载导致小鼠肝脏氧化损伤及葡萄籽原花青素提取物的保护作用。
J Toxicol Sci. 2018;43(5):311-319. doi: 10.2131/jts.43.311.
5
Dysregulation of iron metabolism in cardiovascular diseases: From iron deficiency to iron overload.心血管疾病中铁代谢的失调：从缺铁到铁过载。
Biochem Pharmacol. 2021 Aug;190:114661. doi: 10.1016/j.bcp.2021.114661. Epub 2021 Jun 23.
6
Hepcidin and metallothioneins as molecular base for sex-dependent differences in clinical course of experimental autoimmune encephalomyelitis in chronic iron overload.铁调素和金属硫蛋白作为实验性自身免疫性脑脊髓炎慢性铁过载中性别依赖性临床病程差异的分子基础。
Med Hypotheses. 2017 Sep;107:51-54. doi: 10.1016/j.mehy.2017.07.022. Epub 2017 Jul 20.
7
Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis.过量铁在乳腺癌发生过程中起作用吗？一个尚未解决的假说。
Cancer Causes Control. 2007 Dec;18(10):1047-53. doi: 10.1007/s10552-007-9058-9. Epub 2007 Sep 6.
8
Cardiomyopathy associated with iron overload: how does iron enter myocytes and what are the implications for pharmacological therapy?与铁过载相关的心肌病：铁是如何进入心肌细胞的，以及对药物治疗有何影响？
Hemoglobin. 2015;39(1):9-17. doi: 10.3109/03630269.2014.987869. Epub 2015 Jan 9.
9
The 'incessant menstruation' hypothesis: a mechanistic ovarian cancer model with implications for prevention.“无休止的月经”假说：一种具有预防意义的卵巢癌发生机制模型。
Hum Reprod. 2011 Sep;26(9):2262-73. doi: 10.1093/humrep/der211. Epub 2011 Jun 30.
10
Crosstalk between Iron and Arteriosclerosis.铁与动脉粥样硬化的相互作用。
J Atheroscler Thromb. 2022 Mar 1;29(3):308-314. doi: 10.5551/jat.RV17060. Epub 2021 Aug 20.
引用本文的文献
1
Disulfide-based 2-pyridyl-hydrazone prochelators induce iron deprivation and oxidative stress in ovarian cancer cells.基于二硫键的2-吡啶基腙前螯合剂在卵巢癌细胞中诱导铁剥夺和氧化应激。
J Biol Inorg Chem. 2025 Jul 1. doi: 10.1007/s00775-025-02119-8.
2
The intersection of ferroptosis and non-coding RNAs: a novel approach to ovarian cancer.铁死亡与非编码RNA的交叉：卵巢癌的一种新方法。
Eur J Med Res. 2025 Apr 17;30(1):300. doi: 10.1186/s40001-025-02559-7.
3
Melatonin alleviates ferroptosis triggered by cadmium via regulating ferritinophagy and iron metabolism in spermatogonia.褪黑素通过调节精原细胞中的铁自噬和铁代谢来减轻镉引发的铁死亡。
Sci Rep. 2025 Mar 14;15(1):8910. doi: 10.1038/s41598-025-93822-8.
4
Link between iron-mediated lipid peroxidation and polycystic ovary syndrome (PCOS): exploring the genes underlying iron regulatory mechanism.铁介导的脂质过氧化与多囊卵巢综合征（PCOS）之间的联系：探索铁调节机制背后的基因
J Ovarian Res. 2025 Mar 8;18(1):48. doi: 10.1186/s13048-024-01562-6.
5
Broadening horizons: the role of ferroptosis in polycystic ovary syndrome.拓宽视野：铁死亡在多囊卵巢综合征中的作用。
Front Endocrinol (Lausanne). 2024 Aug 2;15:1390013. doi: 10.3389/fendo.2024.1390013. eCollection 2024.
6
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer.铁螯合疗法引发转移性卵巢癌的固有免疫控制。
Cancer Discov. 2024 Oct 4;14(10):1901-1921. doi: 10.1158/2159-8290.CD-23-1451.
7
Endometriosis-Associated Ovarian Cancer: From Molecular Pathologies to Clinical Relevance.子宫内膜异位症相关卵巢癌：从分子病理学至临床相关性
Int J Mol Sci. 2024 Apr 13;25(8):4306. doi: 10.3390/ijms25084306.
8
Endogenous Microbacteria Can Contribute to Ovarian Carcinogenesis by Reducing Iron Concentration in Cysts: A Pilot Study.内源性微生物可通过降低囊肿中铁浓度促进卵巢癌发生：一项初步研究。
Microorganisms. 2024 Mar 7;12(3):538. doi: 10.3390/microorganisms12030538.
9
Ovaries of estrogen receptor 1-deficient mice show iron overload and signs of aging.雌激素受体1缺陷小鼠的卵巢表现出铁过载和衰老迹象。
Front Endocrinol (Lausanne). 2024 Feb 23;15:1325386. doi: 10.3389/fendo.2024.1325386. eCollection 2024.
10
Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials.癌症中细胞铁死亡与铜死亡的相互作用：剖析金属驱动的治疗潜力机制
Cancers (Basel). 2024 Jan 24;16(3):512. doi: 10.3390/cancers16030512.
本文引用的文献
1
Siderophore-mediated iron acquisition and modulation of host-bacterial interactions.铁载体介导的铁获取及宿主-细菌相互作用的调节
Free Radic Biol Med. 2017 Apr;105:68-78. doi: 10.1016/j.freeradbiomed.2016.10.489. Epub 2016 Oct 22.
2
Nanomedicine: An iron age for cancer therapy.纳米医学：癌症治疗的铁器时代。
Nat Nanotechnol. 2016 Nov;11(11):921-922. doi: 10.1038/nnano.2016.199. Epub 2016 Sep 26.
3
Iron, microbiota and colorectal cancer.铁、微生物群与结直肠癌
Wien Med Wochenschr. 2016 Oct;166(13-14):431-436. doi: 10.1007/s10354-016-0508-4. Epub 2016 Aug 30.
4
One-year results from a prospective randomized trial comparing phlebotomy with deferasirox for the treatment of iron overload in pediatric patients with thalassemia major following curative stem cell transplantation.一项前瞻性随机试验的一年期结果，该试验比较了静脉放血术与地拉罗司治疗重型地中海贫血患儿根治性干细胞移植后铁过载的疗效。
Pediatr Blood Cancer. 2017 Jan;64(1):188-196. doi: 10.1002/pbc.26213. Epub 2016 Aug 31.
5
Ferritin heavy chain is a negative regulator of ovarian cancer stem cell expansion and epithelial to mesenchymal transition.铁蛋白重链是卵巢癌干细胞扩增和上皮-间质转化的负调节因子。
Oncotarget. 2016 Sep 20;7(38):62019-62033. doi: 10.18632/oncotarget.11495.
6
CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation.CISD1通过防止线粒体脂质过氧化来抑制铁死亡。
Biochem Biophys Res Commun. 2016 Sep 16;478(2):838-44. doi: 10.1016/j.bbrc.2016.08.034. Epub 2016 Aug 7.
7
Protective effects of vitamin D3 on fimbrial cells exposed to catalytic iron damage.维生素D3对暴露于催化铁损伤的菌毛细胞的保护作用。
J Ovarian Res. 2016 Jun 17;9(1):34. doi: 10.1186/s13048-016-0243-x.
8
Haemochromatosis and gastrointestinal cancer.血色素沉着症与胃肠道癌
Int J Cancer. 2016 Oct 15;139(8):1740-3. doi: 10.1002/ijc.30229. Epub 2016 Jun 24.
9
Increased concentration of 8-hydroxy-2'-deoxyguanosine in follicular fluid of infertile women with endometriosis.子宫内膜异位症不孕女性卵泡液中8-羟基-2'-脱氧鸟苷浓度升高。
Cell Tissue Res. 2016 Oct;366(1):231-42. doi: 10.1007/s00441-016-2428-4. Epub 2016 Jun 1.
10
Autophagy promotes ferroptosis by degradation of ferritin.自噬通过降解铁蛋白促进铁死亡。
Autophagy. 2016 Aug 2;12(8):1425-8. doi: 10.1080/15548627.2016.1187366. Epub 2016 May 31.
Zotero 插件