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用于检测和光热解聚β-淀粉样蛋白聚集体的自组装脂蛋白基金纳米颗粒。

Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates.

作者信息

Martins P A T, Alsaiari S, Julfakyan K, Nie Z, Khashab N M

机构信息

Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia.

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.

出版信息

Chem Commun (Camb). 2017 Feb 9;53(13):2102-2105. doi: 10.1039/c6cc09085k.

Abstract

We present a reconstituted lipoprotein-based nanoparticle platform comprising a curcumin fluorescent motif and an NIR responsive gold core. This multifunctional nanosystem is successfully used for aggregation-dependent fluorescence detection and photothermal disassembly of insoluble amyloid aggregates.

摘要

我们展示了一种基于重组脂蛋白的纳米颗粒平台,其包含姜黄素荧光基序和近红外响应金核。这种多功能纳米系统成功用于不溶性淀粉样聚集体的聚集依赖性荧光检测和光热拆解。

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