来自秘鲁酸浆果的醉茄内酯具有抑制一氧化氮产生的作用，并与诱导型一氧化氮合酶（iNOS）具有亲和力。
Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS.
机构信息
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300050, People's Republic of China.
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, People's Republic of China.
出版信息
Bioorg Chem. 2019 Jun;87:585-593. doi: 10.1016/j.bioorg.2019.03.051. Epub 2019 Mar 22.
A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.
植物化学研究旨在获得新的一氧化氮（NO）抑制剂，从秘鲁酸浆的全植物中分离得到了五个新的托品烷类化合物。结构是基于广泛的核磁共振波谱数据分析以及时间依赖密度泛函理论（TDDFT）电子圆二色性（ECD）计算来确定的。通过抑制脂多糖刺激的小鼠小胶质细胞 BV-2 细胞中 NO 的释放来检测 NO 抑制作用。分子对接研究表明，生物活性化合物与诱导型一氧化氮合酶（iNOS）蛋白之间存在强烈的相互作用，揭示了生物活性化合物抑制 NO 的潜在机制。
Zotero 插件