Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China.
J Am Chem Soc. 2017 Feb 1;139(4):1388-1391. doi: 10.1021/jacs.6b11234. Epub 2017 Jan 23.
Herein we report a novel, general protocol for distal heteroaryl ipso-migration and its application to the elusive heteroarylation of unactivated alkenes. A set of nitrogen-containing heteroaryl groups showcase the migratory aptitude. This reaction provides a variety of fluoroalkyl functionalized heteroarenes under mild reaction conditions. This is the first report of a difunctionalization of unactivated alkenes with distal heteroaryl migration.
在此，我们报告了一种新颖的、通用的远程杂芳基反位迁移方法及其在难以实现的未活化烯烃杂芳基化中的应用。一组含氮杂芳基基团展示了迁移的能力。该反应在温和的反应条件下提供了多种氟烷基官能化的杂芳烃。这是首例报道的使用远程杂芳基迁移对未活化烯烃进行双官能化的反应。
