Environment, susceptibility windows, development, and child health.

PURPOSE OF REVIEW

To illustrate the role of the exposome in child health while highlighting unique aspects of this research pertinent to children, such as the time dependency of environmental exposures on fetal programming, as well as the time-dependent nature of child behavior, diet, and motor function, which alter the probability of exposure to different compounds. Future environmental health research will be more hypothesis generating but will also need to heed lessons learned from other 'omic' sciences. The NIH Child Health Environmental Analysis Resource (CHEAR) is a major step toward providing the infrastructure needed to study the exposome and child health.

RECENT FINDINGS

Environmental exposures have overlapping mechanisms such as endocrine disruption and oxidative stress, among others. The nature of the long-term health impact of an exposure is dependent not only on dose, but also on the timing of exposure. Advances in exposure science, toxicology, and biostatistics will create new opportunities to identify and better define windows of susceptibility to environmental exposures.

SUMMARY

As exposure science matures, we will better understand the role of environment on health. Linking the exposome with genomics will unlock the root origins of multiple complex diseases.