Wang Li-Xia, Zheng Hai-Rong, Ren Fu-Cai, Chen Tian-Ge, Li Xiang-Mei, Jiang Xian-Jun, Wang Fei
BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
Nat Prod Bioprospect. 2017 Apr;7(2):201-206. doi: 10.1007/s13659-017-0121-2. Epub 2017 Jan 21.
Four hitherto unknown polysubstituted isoflavonoids, including three isoflavans: 7,4'-dihydroxy-8,2',3'-trimethoxyisoflavan (1), 7,2',4'-trihydroxy-8,3'-dimethoxyisoflavan (2), and 7,2',4'-trihydroxy-5-methoxyisoflavan (3), and one prenylated isoflavone cudraisoflavone M (4) were isolated from the ethanol extracts of Spatholobus suberectus (for 1 and 2), Flemingia macrophylla (for 3), and Cudrania cochinchinensis (for 4), respectively. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1 and 4 exhibited weak cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480).
从直立豆（用于化合物1和2）、大叶千斤拔（用于化合物3）和越南柘树（用于化合物4）的乙醇提取物中分别分离出四种前所未知的多取代异黄酮类化合物，包括三种异黄烷：7,4'-二羟基-8,2',3'-三甲氧基异黄烷（1）、7,2',4'-三羟基-8,3'-二甲氧基异黄烷（2）和7,2',4'-三羟基-5-甲氧基异黄烷（3），以及一种异戊烯基化异黄酮——柘树异黄酮M（4）。它们的结构通过广泛的光谱分析得以确定。化合物1和4对五种人类癌细胞系（HL-60、A-549、SMMC-7721、MCF-7和SW-480）表现出微弱的细胞毒性活性。
