West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Molecules. 2019 Sep 4;24(18):3218. doi: 10.3390/molecules24183218.
The rattans of Dunn are a traditional Chinese medicine activating blood circulation and removing stasis. They have often been used for the traditional Chinese medicinal treatment of breast cancer in modern China. In this study, four novel isoflavanes (- and ) and four known analogues ( and -) were isolated from an ethanolic extract of the rattans of . Their structures were elucidated by extensive spectroscopic analyses and electronic circular dichroism studies. MCF-7 and MDA-MB-231 human breast cancer cell lines were used to evaluate the cytotoxic effects of the isolates. Interestingly, compounds and only inhibited the proliferation of MCF-7 cells, while compound showed a selective cytotoxicity against MDA-MB-231 cells. However, compound had significant cytotoxicity against both MCF-7 and MDA-MB-231 cell lines.
邓氏省藤为传统中药，具有活血化瘀的功效，常用于现代中国乳腺癌的中医治疗。在这项研究中，从邓氏省藤的乙醇提取物中分离得到了四种新型异黄烷（-和-）和四种已知类似物（和-）。通过广泛的光谱分析和电子圆二色性研究阐明了它们的结构。 MCF-7 和 MDA-MB-231 人乳腺癌细胞系用于评估分离物的细胞毒性作用。有趣的是，化合物和仅抑制 MCF-7 细胞的增殖，而化合物对 MDA-MB-231 细胞表现出选择性细胞毒性。然而，化合物对 MCF-7 和 MDA-MB-231 细胞系均具有显著的细胞毒性。
