Bosnić Dubravka, Žarković Branimir, Barešić Marko, Zarkovic Maja, Anić Branimir
Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb, School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia.
Division of Rheumatology, Physical Medicine and Rehabilitation, General Hospital "Dr. Josip Benčević", Slavonski Brod, Croatia.
Reumatologia. 2016;54(6):321-325. doi: 10.5114/reum.2016.64910. Epub 2016 Dec 30.
Hidradenitis suppurativa is a chronic inflammatory disorder characterized by occlusion of the follicular pilosebaceous units of the skin. The treatment options are sometimes very limited and unpleasant odor and abundant drainage complicate the disease. Ankylosing spondylitis is a form of seronegative spondyloarthritis with predominantly axial but also peripheral joint involvement. Both of the conditions lower the patient's quality of life and affect everyday activities. We describe a 39-year-old male patient with both diseases treated with different medications with only a modest result. After the initiation of a tumor necrosis factor α (TNF-α) inhibitor (adalimumab) the patient experienced first the musculoskeletal and later on the skin improvement. The introduction of TNF-α inhibitors should be considered early in the treatment of overlapping hidradenitis suppurativa and the spondyloarthritis spectrum of conditions. Available medical data confirm the positive results and beneficial effect on disease course, activity and, most importantly, quality of life.
化脓性汗腺炎是一种慢性炎症性疾病，其特征为皮肤毛囊皮脂腺单位闭塞。治疗选择有时非常有限，且难闻的气味和大量渗液使病情复杂化。强直性脊柱炎是血清阴性脊柱关节炎的一种形式，主要累及中轴关节，但也可累及外周关节。这两种疾病都会降低患者的生活质量并影响日常活动。我们描述了一名39岁的男性患者，同时患有这两种疾病，使用不同药物治疗后效果一般。在开始使用肿瘤坏死因子α（TNF-α）抑制剂（阿达木单抗）后，患者的肌肉骨骼症状首先得到改善，随后皮肤症状也有所改善。在重叠性化脓性汗腺炎和脊柱关节炎谱系疾病的治疗中，应尽早考虑引入TNF-α抑制剂。现有医学数据证实了其积极效果以及对病程、活动度，最重要的是对生活质量的有益影响。
