Jesus Mafalda, Martins Ana P J, Gallardo Eugenia, Silvestre Samuel
CICS-UBI, Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, Portugal.
CICS-UBI, Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, Portugal; Laboratório de Fármaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Covilhã, Portugal.
J Anal Methods Chem. 2016;2016:4156293. doi: 10.1155/2016/4156293. Epub 2016 Dec 28.
Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as , and . This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as cancer, hypercholesterolemia, inflammation, and several types of infections. Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. Within these, HPLC technique coupled to different detectors is the most commonly analytical procedure described for this compound. However, other alternative methods were also published. Thus, the present review aims to provide collective information on the most recent pharmacological data on diosgenin and on the most relevant analytical techniques used to isolate, detect, and quantify this compound as well.
薯蓣皂苷元，一种甾体皂苷元，大量存在于如[此处原文缺失植物名称]、[此处原文缺失植物名称]和[此处原文缺失植物名称]等植物中。这种具有生物活性的植物化学物质不仅在制药工业中用作制备多种甾体药物的重要起始原料，而且在治疗各种疾病如癌症、高胆固醇血症、炎症和多种感染方面也显示出巨大潜力并引起了人们的兴趣。由于其药理学和工业重要性，多年来已经开发并应用了多种提取和分析方法来分离、检测和定量薯蓣皂苷元，不仅用于其天然来源和药物组合物中，还用于动物基质中进行药效学、药代动力学和毒理学研究。其中，与不同检测器联用的高效液相色谱技术是针对该化合物描述最常用的分析方法。然而，也有其他替代方法被报道。因此，本综述旨在提供关于薯蓣皂苷元最新药理学数据以及用于分离、检测和定量该化合物的最相关分析技术的综合信息。
