Pandey Pratibha, Ramniwas Seema, Baldaniya Lalji, Lakhanpal Sorabh, Mahmood Danish, Chaudhary Kamlesh, Pandey Shivam, Choi Min, Choi Jinwon, Kim Hyo Jeong, Ahn Chi-Hoon, Park Moon Nyeo, Khan Fahad, Kim Bonglee
Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, 140401, India.
Chitkara Centre for Research and Development, Chitkara University Himachal Pradesh, Baddi, India.
Drug Des Devel Ther. 2025 Mar 24;19:2205-2227. doi: 10.2147/DDDT.S502322. eCollection 2025.
Dietary components have gained broader recognition in preventing and managing numerous human carcinomas. Plant-derived natural compounds offer several benefits, including their limited toxicity and multi-targeted agents in modulating deregulated oncogenic pathways, including PI3K/AKT, NF-κB/STAT3, and HIF-1α, and hence, they emerged as better chemotherapeutic alternatives. Diosgenin (phytosteroidal saponin) and its nanoformulations have been extensively reported to impact cancer progression and metastasis. Research has indicated that diosgenin and its nanoformulations possess significant anticancer potential with improved bioavailability. However, novelty of this review relies on compiling the updated anticancer role of diosgenin and its nanoformulations in modulating numerous oncogenic targets associated with carcinogenesis and metastasis. Diosgenin has also been utilized with traditional therapies to enhance the sensitivity of cancerous cells towards normal chemotherapeutic processes. More focus should be given to gain detailed insights about the mechanisms associated with the anticancer potential of diosgenin and its nanoformulations, which can further potentiate its candidature in developing efficient cancer therapies. However, more preclinical studies are warranted to exploit the anticancer efficacy of this plant-based compound in an efficient manner.
饮食成分在预防和管理多种人类癌症方面已获得更广泛的认可。植物来源的天然化合物具有多种益处，包括其毒性有限以及作为多靶点药物可调节失调的致癌途径，如PI3K/AKT、NF-κB/STAT3和HIF-1α，因此，它们成为了更好的化疗替代方案。薯蓣皂苷元（植物甾体皂苷）及其纳米制剂已被广泛报道对癌症进展和转移有影响。研究表明，薯蓣皂苷元及其纳米制剂具有显著的抗癌潜力且生物利用度有所提高。然而，本综述的新颖之处在于汇总薯蓣皂苷元及其纳米制剂在调节与致癌作用和转移相关的众多致癌靶点方面的最新抗癌作用。薯蓣皂苷元也已与传统疗法联合使用，以增强癌细胞对正常化疗过程的敏感性。应更加关注深入了解与薯蓣皂苷元及其纳米制剂抗癌潜力相关的机制，这可进一步提升其在开发高效癌症治疗方法中的候选资格。然而，需要更多的临床前研究来有效利用这种基于植物的化合物的抗癌功效。
