Contado Catia
Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via L. Borsari 46, 44121, Ferrara, Italy.
Anal Bioanal Chem. 2017 Apr;409(10):2501-2518. doi: 10.1007/s00216-017-0180-6. Epub 2017 Jan 23.
Field flow fractionation (FFF) techniques are used to successfully characterize several nanomaterials by sizing nano-entities and producing information about the aggregation/agglomeration state of nanoparticles. By coupling FFF techniques to specific detectors, researchers can determine particle-size distributions (PSDs), expressed as mass-based or number-based PSDs. This review considers FFF applications in the food, biomedical, and environmental sectors, mostly drawn from the past 4 y. It thus underlines the prominent role of asymmetrical flow FFF within the FFF family. By concisely comparing FFF techniques with other techniques suitable for sizing nano-objects, the advantages and the disadvantages of these instruments become clear. A consideration of select recent publications illustrates the state of the art of some lesser-known FFF techniques and innovative instrumental set-ups.
场流分级（FFF）技术通过对纳米实体进行尺寸测量并生成有关纳米颗粒聚集/团聚状态的信息，成功地对几种纳米材料进行了表征。通过将FFF技术与特定探测器相结合，研究人员可以确定颗粒尺寸分布（PSD），以基于质量或基于数量的PSD表示。本综述主要考虑了过去4年中FFF在食品、生物医学和环境领域的应用。因此，它强调了不对称流FFF在FFF家族中的突出作用。通过简要地将FFF技术与其他适用于纳米物体尺寸测量的技术进行比较，这些仪器的优缺点变得清晰明了。对一些近期出版物的考量说明了一些鲜为人知的FFF技术和创新仪器设置的现状。
